All Outputs (60)
Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear (2023)
Journal Article
Contextual fear conditioning (CFC) is mediated by a neural circuit that includes the hippocampus, prefrontal cortex, and amygdala, but the neurophysiological mechanisms underlying the regulation of CFC by neuromodulators remain unclear. Dopamine D1-l... Read More about Dopamine D1-like receptors modulate synchronized oscillations in the hippocampal–prefrontal–amygdala circuit in contextual fear.
Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries (2023)
Journal Article
Three groups of participants (largely recruited from the UK) completed a survey to examine attitudes to the use of animals in biomedical research, after reading the lay (N = 182) or technical (N = 201) summary of a research project, or no summary (N... Read More about Attitudes to the use of animals in biomedical research: Effects of stigma and selected research project summaries.
From safety to frustration: The neural substrates of inhibitory learning in aversive and appetitive conditioning procedures (2023)
Journal Article
Inhibitory associative learning counters the effects of excitatory learning, whether appetitively or aversively motivated. Moreover, the affective responses accompanying the inhibitory associations are of opponent valence to the excitatory conditione... Read More about From safety to frustration: The neural substrates of inhibitory learning in aversive and appetitive conditioning procedures.
Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats (2022)
Journal Article
Endocannabinoid transmission is emerging as a target for treating anxiety-related disorders, given its regulation of fear extinction. Boosting anandamide levels via inhibition of its metabolism by fatty acid amide hydrolase (FAAH) can enhance extinct... Read More about Endocannabinoid metabolism inhibition has no effect on spontaneous fear recovery or extinction resistance in Lister hooded rats.
Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance (2022)
Journal Article
Cannabidiol, the main non-psychotropic constituent of cannabis, has potential as a treatment for anxiety-related disorders since it reduces learned fear expression and enhances fear extinction. The return of fear over time after successful extinction... Read More about Cannabidiol Prevents Spontaneous Fear Recovery after Extinction and Ameliorates Stress-Induced Extinction Resistance.
URB597 induces subtle changes to aggression in adult Lister Hooded rats (2022)
Journal Article
The endocannabinoid system has been implicated in both social and cognitive processing. The endocannabinoid metabolism inhibitor, URB597, dose-dependently improves non-social memory in adult Wistar and Sprague Dawley rats, whereas its effect on socia... Read More about URB597 induces subtle changes to aggression in adult Lister Hooded rats.
Attitudes to animal use of named species for different purposes: effects of speciesism, individualising morality, likeability and demographic factors (2022)
Journal Article
Attitudes to animals and their use are becoming increasingly important for the success of conservation and environmental initiatives. Beliefs about animals, their perceived emotional appeal, as well as individuals’ moral capacities are all likely dri... Read More about Attitudes to animal use of named species for different purposes: effects of speciesism, individualising morality, likeability and demographic factors.
Safety Learning in Anxiety, Pavlovian Conditioned Inhibition and COVID Concerns (2022)
Journal Article
Experimental studies of fear conditioning have identified the effectiveness of safety signals in inhibiting fear and maintaining fear-motivated behaviors. In fear conditioning procedures, the presence of safety signals means that the otherwise expect... Read More about Safety Learning in Anxiety, Pavlovian Conditioned Inhibition and COVID Concerns.
Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition (2022)
Journal Article
Hippocampal neural disinhibition, i.e., reduced GABAergic inhibition, is a key feature of schizophrenia pathophysiology. The hippocampus is an important part of the neural circuitry that controls fear conditioning and can also modulate prefrontal and... Read More about Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition.
Strain comparisons in inhibitory discrimination learning and novel object recognition procedures (2021)
Journal Article
Strain differences in visual abilities and exploratory tendencies can confound rats’ performance in cognitive tests of learning and memory. In the present study we compared the performance of albino Wistar and pigmented Lister Hooded rats in appetiti... Read More about Strain comparisons in inhibitory discrimination learning and novel object recognition procedures.
Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition (2021)
Working Paper
Hippocampal neural disinhibition, i.e. reduced GABAergic inhibition, is a key feature of schizophrenia pathophysiology. The hippocampus is an important part of the neural circuitry that controls fear conditioning and can also modulate prefrontal and... Read More about Hippocampal disinhibition reduces contextual and elemental fear conditioning while sparing the acquisition of latent inhibition.
Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat (2020)
Journal Article
Previous studies suggest that trace conditioning depends on the anterior cingulate cortex (ACC). To examine the role of ACC in trace fear conditioning further, 48 rats were surgically prepared for infusion with saline or 62.5 or 125 µg/side muscimol... Read More about Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat.
Man's best friends: attitudes towards the use of different kinds of animal depend on belief in different species' mental capacities and purpose of use (2020)
Journal Article
The animal purpose questionnaire (APQ) is a new instrument to measure human attitudes to animal use systematically across both species and purpose of use. This offers a more fine-grained approach to our understanding of how the belief in a specific a... Read More about Man's best friends: attitudes towards the use of different kinds of animal depend on belief in different species' mental capacities and purpose of use.
Some animals are more equal than others: Validation of a new scale to measure how attitudes to animals depend on species and human purpose of use (2020)
Journal Article
© 2020 Bradley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cr... Read More about Some animals are more equal than others: Validation of a new scale to measure how attitudes to animals depend on species and human purpose of use.
Anterior Cingulate Cortex (2020)
Book Chapter
Data showing regional differences in rat brain monoaminergic function (2019)
Journal Article
Chemical neurotransmitters (such as dopamine) modulate cognitive function via ascending projections to various cortical and sub-cortical brain regions. This report describes and links to a relatively large dataset (up to N=112) compiled from control... Read More about Data showing regional differences in rat brain monoaminergic function.
Intraperitoneal 8-OH-DPAT reduces competition from contextual but not discrete conditioning cues (2019)
Journal Article
The effects of the serotonergic (5-hydroxytryptamine, 5-HT) agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 0.2 and 0.4 mg/kg i.p.) were examined in trace conditioning (Experiment 1) and overshadowing (Experiment 2) procedures. Both experi... Read More about Intraperitoneal 8-OH-DPAT reduces competition from contextual but not discrete conditioning cues.
EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli (2019)
Journal Article
Activation of 5-HT6 receptors stimulates attentional switching and 5-HT6 receptor antagonists are putative drugs for psychosis. Latent inhibition (LI) provides a pre-clinical model of attentional switching and ‘antipsychotic-like’ action and is known... Read More about EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli.
Age-related differences in appetitive trace conditioning and novel object recognition procedures (2019)
Journal Article
Appetitive trace conditioning (TC) was examined over 6 months in younger-adult (2-8 months) and middle-aged (12-18 months) male Wistar RccHan rats to test for early age-related impairment in working memory. Novel object recognition (NOR) was included... Read More about Age-related differences in appetitive trace conditioning and novel object recognition procedures.