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EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli

Cassaday, Helen Joan; Thur, Karen Elizabeth

Authors

Helen Joan Cassaday

Karen Elizabeth Thur



Abstract

Activation of 5-HT6 receptors stimulates attentional switching and 5-HT6 receptor antagonists are putative drugs for psychosis. Latent inhibition (LI) provides a pre-clinical model of attentional switching and ‘antipsychotic-like’ action and is known to be modulated by 5-HT. In the present study, LI was shown in a fear conditioning procedure which measured suppression of drinking after conditioning with footshock. In two experiments (each N=48) it was shown that pre-exposure to both light and noise conditioned stimuli reduced conditioned suppression relative to the corresponding non-pre-exposed control. However, counter to prediction, LI was intact after treatment with the 5-HT6 agonist EMD386088 (5mg/kg).

Journal Article Type Article
Publication Date Oct 17, 2019
Journal Journal of Psychopharmacology
Print ISSN 0269-8811
Electronic ISSN 1461-7285
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
APA6 Citation Cassaday, H. J., & Thur, K. E. (2019). EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli. Journal of Psychopharmacology, https://doi.org/10.1177/0269881119882855
DOI https://doi.org/10.1177/0269881119882855
Keywords fear conditioning, latent inhibition, 5-hydroxytyptamine, EMD386088
Publisher URL https://journals.sagepub.com/doi/10.1177/0269881119882855

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