EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli

Cassaday, Helen Joan; Thur, Karen Elizabeth

Abstract

Activation of 5-HT6 receptors stimulates attentional switching and 5-HT6 receptor antagonists are putative drugs for psychosis. Latent inhibition (LI) provides a pre-clinical model of attentional switching and ‘antipsychotic-like’ action and is known to be modulated by 5-HT. In the present study, LI was shown in a fear conditioning procedure which measured suppression of drinking after conditioning with footshock. In two experiments (each N=48) it was shown that pre-exposure to both light and noise conditioned stimuli reduced conditioned suppression relative to the corresponding non-pre-exposed control. However, counter to prediction, LI was intact after treatment with the 5-HT6 agonist EMD386088 (5mg/kg).

Citation

Cassaday, H. J., & Thur, K. E. (2020). EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli. Journal of Psychopharmacology, 34(1), 145-147. https://doi.org/10.1177/0269881119882855

• Journal Article Type: Article
• Acceptance Date: Sep 23, 2019
• Online Publication Date: Oct 17, 2019
• Publication Date: Jan 1, 2020
• Deposit Date: Sep 27, 2019
• Publicly Available Date: Sep 27, 2019
• Journal: Journal of Psychopharmacology
• Print ISSN: 0269-8811
• Electronic ISSN: 1461-7285
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 34
• Issue: 1
• Pages: 145-147
• DOI: https://doi.org/10.1177/0269881119882855
• Keywords: fear conditioning, latent inhibition, 5-hydroxytyptamine, EMD386088
• Public URL: https://nottingham-repository.worktribe.com/output/2693423
• Publisher URL: https://journals.sagepub.com/doi/10.1177/0269881119882855