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EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli

Cassaday, Helen Joan; Thur, Karen Elizabeth

Authors

HELEN CASSADAY HELEN.CASSADAY@NOTTINGHAM.AC.UK
Professor of Behavioural Neuroscience

Karen Elizabeth Thur



Abstract

Activation of 5-HT6 receptors stimulates attentional switching and 5-HT6 receptor antagonists are putative drugs for psychosis. Latent inhibition (LI) provides a pre-clinical model of attentional switching and ‘antipsychotic-like’ action and is known to be modulated by 5-HT. In the present study, LI was shown in a fear conditioning procedure which measured suppression of drinking after conditioning with footshock. In two experiments (each N=48) it was shown that pre-exposure to both light and noise conditioned stimuli reduced conditioned suppression relative to the corresponding non-pre-exposed control. However, counter to prediction, LI was intact after treatment with the 5-HT6 agonist EMD386088 (5mg/kg).

Citation

Cassaday, H. J., & Thur, K. E. (2020). EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli. Journal of Psychopharmacology, 34(1), 145-147. https://doi.org/10.1177/0269881119882855

Journal Article Type Article
Acceptance Date Sep 23, 2019
Online Publication Date Oct 17, 2019
Publication Date Jan 1, 2020
Deposit Date Sep 27, 2019
Publicly Available Date Sep 27, 2019
Journal Journal of Psychopharmacology
Print ISSN 0269-8811
Electronic ISSN 1461-7285
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 34
Issue 1
Pages 145-147
DOI https://doi.org/10.1177/0269881119882855
Keywords fear conditioning, latent inhibition, 5-hydroxytyptamine, EMD386088
Public URL https://nottingham-repository.worktribe.com/output/2693423
Publisher URL https://journals.sagepub.com/doi/10.1177/0269881119882855

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