Helen Joan Cassaday
EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli
Cassaday, Helen Joan; Thur, Karen Elizabeth
Authors
Karen Elizabeth Thur
Abstract
Activation of 5-HT6 receptors stimulates attentional switching and 5-HT6 receptor antagonists are putative drugs for psychosis. Latent inhibition (LI) provides a pre-clinical model of attentional switching and ‘antipsychotic-like’ action and is known to be modulated by 5-HT. In the present study, LI was shown in a fear conditioning procedure which measured suppression of drinking after conditioning with footshock. In two experiments (each N=48) it was shown that pre-exposure to both light and noise conditioned stimuli reduced conditioned suppression relative to the corresponding non-pre-exposed control. However, counter to prediction, LI was intact after treatment with the 5-HT6 agonist EMD386088 (5mg/kg).
Citation
Cassaday, H. J., & Thur, K. E. (2020). EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli. Journal of Psychopharmacology, 34(1), 145-147. https://doi.org/10.1177/0269881119882855
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 23, 2019 |
Online Publication Date | Oct 17, 2019 |
Publication Date | Jan 1, 2020 |
Deposit Date | Sep 27, 2019 |
Publicly Available Date | Sep 27, 2019 |
Journal | Journal of Psychopharmacology |
Print ISSN | 0269-8811 |
Electronic ISSN | 1461-7285 |
Publisher | SAGE Publications |
Peer Reviewed | Peer Reviewed |
Volume | 34 |
Issue | 1 |
Pages | 145-147 |
DOI | https://doi.org/10.1177/0269881119882855 |
Keywords | fear conditioning, latent inhibition, 5-hydroxytyptamine, EMD386088 |
Public URL | https://nottingham-repository.worktribe.com/output/2693423 |
Publisher URL | https://journals.sagepub.com/doi/10.1177/0269881119882855 |
Contract Date | Sep 27, 2019 |
Files
EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli
(207 Kb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search