@article { , title = {EMD386088 (5 mg/kg) has no effect on latent inhibition shown to both light and noise stimuli}, abstract = {Activation of 5-HT6 receptors stimulates attentional switching and 5-HT6 receptor antagonists are putative drugs for psychosis. Latent inhibition (LI) provides a pre-clinical model of attentional switching and ‘antipsychotic-like’ action and is known to be modulated by 5-HT. In the present study, LI was shown in a fear conditioning procedure which measured suppression of drinking after conditioning with footshock. In two experiments (each N=48) it was shown that pre-exposure to both light and noise conditioned stimuli reduced conditioned suppression relative to the corresponding non-pre-exposed control. However, counter to prediction, LI was intact after treatment with the 5-HT6 agonist EMD386088 (5mg/kg).}, doi = {10.1177/0269881119882855}, eissn = {1461-7285}, issn = {0269-8811}, issue = {1}, journal = {Journal of Psychopharmacology}, pages = {145-147}, publicationstatus = {Published}, publisher = {SAGE Publications}, url = {https://nottingham-repository.worktribe.com/output/2693423}, volume = {34}, keyword = {fear conditioning, latent inhibition, 5-hydroxytyptamine, EMD386088}, year = {2020}, author = {Cassaday, Helen Joan and Thur, Karen Elizabeth} }