Muscimol-induced inactivation of the anterior cingulate cortex does not impair trace fear conditioning in the rat

Pezze, M A; Marshall, H J; Cassaday, H J

Abstract

Previous studies suggest that trace conditioning depends on the anterior cingulate cortex (ACC). To examine the role of ACC in trace fear conditioning further, 48 rats were surgically prepared for infusion with saline or 62.5 or 125 µg/side muscimol to inactivate ACC reversibly prior to conditioning. A noise stimulus was followed by a 1 mA footshock, with or without a 10-second trace interval between these events in a conditioned suppression procedure. The trace-conditioned groups (10 seconds) showed less test suppression than the control-conditioned groups (0 seconds). Counter to prediction, there was no effect of muscimol infusion on suppression to the noise stimulus in the 10-second trace groups.

• Journal Article Type: Article
• Acceptance Date: Aug 28, 2020
• Online Publication Date: Nov 8, 2020
• Publication Date: Dec 1, 2020
• Deposit Date: Sep 10, 2020
• Publicly Available Date: Nov 8, 2020
• Journal: Journal of Psychopharmacology
• Print ISSN: 0269-8811
• Electronic ISSN: 1461-7285
• Publisher: SAGE Publications
• Peer Reviewed: Peer Reviewed
• Volume: 34
• Issue: 12
• Pages: 1457-1460
• DOI: https://doi.org/10.1177/0269881120965914
• Keywords: Reversible inactivation, muscimol, anterior cingulate cortex, trace conditioning, contextual conditioning, rat
• Public URL: https://nottingham-repository.worktribe.com/output/4895313
• Publisher URL: https://journals.sagepub.com/doi/full/10.1177/0269881120965914