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A new framework for characterization of poroelastic materials using indentation (2019)
Journal Article
Esteki, M. H., Alemrajabi, A. A., Hall, C., Sheridan, G. K., Azadi, M., & Moeendarbary, E. (2020). A new framework for characterization of poroelastic materials using indentation. Acta Biomaterialia, 102, 138-148. https://doi.org/10.1016/j.actbio.2019.11.010

To characterize a poroelastic material, typically an indenter is pressed onto the surface of the material with a ramp of a finite approach velocity followed by a hold where the indenter displacement is kept constant. This leads to deformation of the... Read More about A new framework for characterization of poroelastic materials using indentation.

Inhibition of Piezo1 attenuates demyelination in the central nervous system (2019)
Journal Article
Velasco‐Estevez, M., Gadalla, K. K. E., Liñan‐Barba, N., Cobb, S., Dev, K. K., & Sheridan, G. K. (2019). Inhibition of Piezo1 attenuates demyelination in the central nervous system. Glia, https://doi.org/10.1002/glia.23722

Piezo1 is a mechanosensitive ion channel that facilitates the translation of extracellular mechanical cues to intracellular molecular signaling cascades through a process termed, mechanotransduction. In the central nervous system (CNS), mechanically... Read More about Inhibition of Piezo1 attenuates demyelination in the central nervous system.

Piezo1 regulates calcium oscillations and cytokine release from astrocytes (2019)
Journal Article
Sheridan, G. K., Velasco‐Estevez, M., Dev, K. K., Rolle, S. O., & Mampay, M. (2020). Piezo1 regulates calcium oscillations and cytokine release from astrocytes. Glia, 68(1), 145-160. https://doi.org/10.1002/glia.23709

Astrocytes are important for information processing in the brain and they achieve this by fine‐tuning neuronal communication via continuous uptake and release of biochemical modulators of neurotransmission and synaptic plasticity. Often overlooked ar... Read More about Piezo1 regulates calcium oscillations and cytokine release from astrocytes.

Spatiotemporally Super-Resolved Volumetric Traction Force Microscopy (2019)
Journal Article
Colin-York, H., Javanmardi, Y., Barbieri, L., Li, D., Korobchevskaya, K., Guo, Y., …Fritzsche, M. (2019). Spatiotemporally Super-Resolved Volumetric Traction Force Microscopy. Nano Letters, 19(7), 4427-4434. https://doi.org/10.1021/acs.nanolett.9b01196

Quantification of mechanical forces is a major challenge across biomedical sciences. Yet such measurements are essential to understanding the role of biomechanics in cell regulation and function. Traction force microscopy remains the most broadly app... Read More about Spatiotemporally Super-Resolved Volumetric Traction Force Microscopy.

Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia (2018)
Journal Article
O'Sullivan, S. A., O'Sullivan, C., Healy, L. M., Dev, K. K., & Sheridan, G. K. (2018). Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia. Journal of Neurochemistry, 144(6), 736-747. https://doi.org/10.1111/jnc.14313

© 2018 International Society for Neurochemistry. Sphingosine 1-phosphate receptors (S1PR) are G protein-coupled and compose a family with five subtypes, S1P1R–S1P5R. The drug Gilenya ® (Novartis, Basel, Switzerland) (Fingolimod; FTY720) targets S1PRs... Read More about Sphingosine 1-phosphate receptors regulate TLR4-induced CXCL5 release from astrocytes and microglia.

The soft mechanical signature of glial scars in the central nervous system (2017)
Journal Article
Sheridan, G. K., Moeendarbary, E., Weber, I. P., Koser, D. E., Soleman, S., Haenzi, B., …Franze, K. (2017). The soft mechanical signature of glial scars in the central nervous system. Nature Communications, 8(1), https://doi.org/10.1038/ncomms14787

© The Author(s) 2017. Injury to the central nervous system (CNS) alters the molecular and cellular composition of neural tissue and leads to glial scarring, which inhibits the regrowth of damaged axons. Mammalian glial scars supposedly form a chemica... Read More about The soft mechanical signature of glial scars in the central nervous system.

Mechanosensing is critical for axon growth in the developing brain (2016)
Journal Article
Koser, D. E., Thompson, A. J., Foster, S. K., Dwivedy, A., Pillai, E. K., Sheridan, G. K., …Franze, K. (2016). Mechanosensing is critical for axon growth in the developing brain. Nature Neuroscience, 19(12), 1592-1598. https://doi.org/10.1038/nn.4394

© 2016 Nature America, Inc., part of Springer Nature. All rights reserved. During nervous system development, neurons extend axons along well-defined pathways. The current understanding of axon pathfinding is based mainly on chemical signaling. Howev... Read More about Mechanosensing is critical for axon growth in the developing brain.

CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity (2014)
Journal Article
Sheridan, G. K., Wdowicz, A., Pickering, M., Watters, O., Halley, P., O'Sullivan, N. C., …Murphy, K. J. (2014). CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity. Frontiers in Cellular Neuroscience, 8, https://doi.org/10.3389/fncel.2014.00233

Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia, and microglia. In particular, cytokines and chemokines can affect cardinal cellula... Read More about CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity.

Theta-Burst Stimulation of Hippocampal Slices Induces Network-Level Calcium Oscillations and Activates Analogous Gene Transcription to Spatial Learning (2014)
Journal Article
Murphy, K. J., Sheridan, G. K., O'Connor, J. J., Moeendarbary, E., & Pickering, M. (2014). Theta-Burst Stimulation of Hippocampal Slices Induces Network-Level Calcium Oscillations and Activates Analogous Gene Transcription to Spatial Learning. PLoS ONE, 9(6), https://doi.org/10.1371/journal.pone.0100546

Over four decades ago, it was discovered that high-frequency stimulation of the dentate gyrus induces long-term potentiation (LTP) of synaptic transmission. LTP is believed to underlie how we process and code external stimuli before converting it to... Read More about Theta-Burst Stimulation of Hippocampal Slices Induces Network-Level Calcium Oscillations and Activates Analogous Gene Transcription to Spatial Learning.

Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations (2014)
Journal Article
Sheridan, G. K., & Dev, K. K. (2014). Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations. Scientific Reports, 4(1), https://doi.org/10.1038/srep05051

Fingolimod (FTY720) is an oral therapy for relapsing remitting multiple sclerosis (MS) and targets sphingosine 1-phosphate receptors (S1PRs). FTY720 also rescues animals from experimental autoimmune encephalomyelitis (EAE), an animal model of MS. The... Read More about Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations.