Research Repository

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Stroking modulates noxious-evoked brain activity in human infants (2018)
Journal Article
Gursul, D., Goksan, S., Hartley, C., Mellado, G. S., Moultrie, F., Hoskin, A., …Slater, R. (2018). Stroking modulates noxious-evoked brain activity in human infants. Current Biology, 28(24), R1380-R1381. doi:10.1016/j.cub.2018.11.014

A subclass of C fibre sensory neurons found in hairy skin are activated by gentle touch [1] and respond optimally to stroking at ∼1–10 cm/s, serving a protective function by promoting affiliative behaviours. In adult humans, stimulation of these C-ta... Read More

Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays (2018)
Journal Article
Greenspon, C. M., Battell, E. E., Devonshire, I. M., Donaldson, L. F., Chapman, V., & Hathway, G. J. (2019). Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays. Journal of Physiology, 597(2), 377-397. doi:10.1113/jp277036

The dorsal spinal cord (DH) is a complex laminar structure integrating peripheral signals into the central nervous system. Spinal somatosensory processing is commonly measured electrophysiologically in vivo by recording the activity of individual Wid... Read More

The influence of the descending pain modulatory system on infant pain-related brain activity (2018)
Journal Article
Goksan, S., Baxter, L., Moultrie, F., Duff, E., Hathway, G., Hartley, C., …Slater, R. (2018). The influence of the descending pain modulatory system on infant pain-related brain activity. eLife, 7, doi:10.7554/elife.37125. ISSN 2050-084X

The descending pain modulatory system (DPMS) constitutes a network of widely distributed brain regions whose integrated function is essential for effective modulation of sensory input to the central nervous system and behavioural responses to pain. A... Read More

Differential contributions of peripheral and central mechanisms to pain in a rodent model of osteoarthritis (2018)
Journal Article
Haywood, A. R., Hathway, G. J., & Chapman, V. (in press). Differential contributions of peripheral and central mechanisms to pain in a rodent model of osteoarthritis. Scientific Reports, 8, doi:10.1038/s41598-018-25581-8. ISSN 2045-2322

The mechanisms underlying the transition from acute nociceptive pain to centrally maintained chronic pain are not clear. We have studied the contributions of the peripheral and central nervous systems during the development of osteoarthritis (OA) pai... Read More

Cancer chemotherapy in early life significantly alters the maturation of pain processing (2017)
Journal Article
Hathway, G. J., Murphy, E., Lloyd, J., Greenspon, C. M., & Hulse, R. P. (2017). Cancer chemotherapy in early life significantly alters the maturation of pain processing. Neuroscience, doi:10.1016/j.neuroscience.2017.11.032. ISSN 0306-4522

Advances in paediatric cancer treatment have led to a ten year survival rate greater than 75%. Platinum-based chemotherapies (e.g.cisplatin) induce peripheral sensory neuropathy in adult and paedriatric cancer patients. The period from birth through... Read More

Age dependent plasticity in endocannabinoid modulation of pain processing through postnatal development (2017)
Journal Article
H-T. Kwok, C., Devonshire, I. M., Imraish, A., Greenspon, C. M., Lockwood, S., Fielden, C., …Hathway, G. J. (2017). Age dependent plasticity in endocannabinoid modulation of pain processing through postnatal development. PAIN, 158(11), doi:10.1097/j.pain.0000000000001027. ISSN 0304-3959

Significant age and experience-dependent remodelling of spinal and supraspinal neural networks occur resulting in altered pain responses in early life. In adults endogenous opioid peptide and endocannabinoid (ECs) pain control systems exist which mod... Read More

Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models (2016)
Journal Article
Meesawatsom, P., Burston, J., Hathway, G., Bennett, A., & Chapman, V. (2016). Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models. Journal of Neuroinflammation, 13(233), doi:10.1186/s12974-016-0676-6. ISSN 1742-2094

Background: Harnessing the actions of the resolvin pathways has the potential for the treatment of a wide range of conditions associated with overt inflammatory signalling. Aspirin-triggered resolvin D1 (AT-RvD1) has robust analgesic effects in behav... Read More

Neuron-immune mechanisms contribute to pain in early stages of arthritis (2016)
Journal Article
Nieto, F. R., Clark, A. K., Grist, J., Hathway, G. J., Chapman, V., & Malcangio, M. (2016). Neuron-immune mechanisms contribute to pain in early stages of arthritis. Journal of Neuroinflammation, 13, doi:10.1186/s12974-016-0556-0. ISSN 1742-2094

Background: Rheumatoid arthritis (RA) patients frequently show weak correlations between the magnitude of pain and inflammation suggesting that mechanisms other than overt peripheral inflammation contribute to pain in RA. We assessed changes in micro... Read More

A quantification of the relationship between neuronal responses in the rat rostral ventromedial medulla and noxious stimulation-evoked withdrawal reflexes (2015)
Journal Article
noxious stimulation-evoked withdrawal reflexes. European Journal of Neuroscience, 42(1), doi:10.1111/ejn.12942. ISSN 0953-816X

The rostral ventromedial medulla (RVM) regulates a range of involuntary behaviours but is most often associated with nociception via the action of pronociceptive ON cells and antinociceptive OFF cells. The phasic responses of ON and OFF cells determi... Read More

Surgical injury in the neonatal rat alters the adult pattern of descending modulation from the rostroventral medulla (2015)
Journal Article
Walker, S. M., Fitzgerald, M., & Hathway, G. J. (2015). Surgical injury in the neonatal rat alters the adult pattern of descending modulation from the rostroventral medulla. Anesthesiology, 122(6), doi:10.1097/ALN.0000000000000658. ISSN 0003-3022

Background: Neonatal pain and injury can alter long-term sensory thresholds. Descending rostroventral medulla (RVM) pathways can inhibit or facilitate spinal nociceptive processing in adulthood. As these pathways undergo significant postnatal maturat... Read More

Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat (2014)
Journal Article
Bennett, A., Kwok, C. H., Devonshire, I. M., & Hathway, G. J. (2014). Postnatal maturation of endogenous opioid systems within the periaqueductal grey and spinal dorsal horn of the rat. PAIN, 155(1), 168-178. doi:10.1016/j.pain.2013.09.022

Significant opioid-dependent changes occur during the fourth postnatal week in supraspinal sites (rostroventral medulla [RVM], periaqueductal grey [PAG]) that are involved in the descending control of spinal excitability via the dorsal horn (DH). Her... Read More

Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain (2013)
Journal Article
Kelly, S., Chapman, R., Woodhams, S., Sagar, D. R., Turner, J., Burston, J., …Chapman, V. (in press). Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain. Annals of the Rheumatic Diseases, 74, doi:10.1136/annrheumdis-2013-203413. ISSN 0003-4967

Objectives Blockade of transient receptor potential vanilloid 1 (TRPV1) with systemic antagonists attenuates osteoarthritis (OA) pain behaviour in rat models, but on-target-mediated hyperthermia has halted clinical trials. The present study investiga... Read More