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Cancer chemotherapy in early life significantly alters the maturation of pain processing

Hathway, Gareth J.; Murphy, Emily; Lloyd, Joseph; Greenspon, Charles M.; Hulse, Richard P.

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Authors

Emily Murphy

Joseph Lloyd

Charles M. Greenspon

Richard P. Hulse



Abstract

Advances in paediatric cancer treatment have led to a ten year survival rate greater than 75%. Platinum-based chemotherapies (e.g.cisplatin) induce peripheral sensory neuropathy in adult and paedriatric cancer patients. The period from birth through to adulthood represents a period of maturation within nociceptive systems. Here we investigated how cisplatin impacts upon postnatal maturation of nociceptive systems. Neonatal Wistar rats (Postnatal day (P) 7) were injected (i.p.) daily with either vehicle (PBS) or cisplatin (1mg/kg) for five consecutive days. Neither group developed mechanical or thermal hypersensitivity immediately during or after treatment. At P22 the cisplatin group developed mechanical (P

Citation

Hathway, G. J., Murphy, E., Lloyd, J., Greenspon, C. M., & Hulse, R. P. (2017). Cancer chemotherapy in early life significantly alters the maturation of pain processing. Neuroscience, https://doi.org/10.1016/j.neuroscience.2017.11.032

Journal Article Type Article
Acceptance Date Nov 17, 2017
Online Publication Date Dec 2, 2017
Publication Date Dec 2, 2017
Deposit Date Nov 30, 2017
Publicly Available Date Dec 2, 2017
Journal Neuroscience
Print ISSN 0306-4522
Electronic ISSN 1873-7544
Publisher Elsevier
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1016/j.neuroscience.2017.11.032
Keywords cisplatin; neuropathy; pain; hyperalgesia; development; postnatal
Public URL https://nottingham-repository.worktribe.com/output/897650
Publisher URL https://www.sciencedirect.com/science/article/pii/S0306452217308266
Contract Date Nov 30, 2017

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