All Outputs (7)

Accurate identification of hospital admissions from care homes: development and validation of an automated algorithm (2017)
Journal Article
Housley, G., Lewis, S., Usman, A., Gordon, A. L., & Shaw, D. E. (2018). Accurate identification of hospital admissions from care homes: development and validation of an automated algorithm. Age and Ageing, 47(3), 387-391. https://doi.org/10.1093/ageing/afx182

Background: measuring the complex needs of care home residents is crucial for resource allocation. Hospital patient administration systems (PAS) may not accurately identify admissions from care homes. Objective: to develop and validate an accurate,... Read More about Accurate identification of hospital admissions from care homes: development and validation of an automated algorithm.

Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma (2017)
Journal Article
Hekking, P., Loza, M. J., Pavlidis, S., De Meulder, B., Lefaudeux, D., Baribaud, F., …Sterk, P. J. (2017). Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma. European Respiratory Journal, 50(3), https://doi.org/10.1183/13993003.02298-2016

A proportion of severe asthma patients suffers from persistent airflow limitation (PAL), often associated with more symptoms and exacerbations. Little is known about the underlying mechanisms. Here, our aim was to discover unexplored potential mechan... Read More about Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma.

Pathway discovery using transcriptomic profiles in adult-onset severe asthma (2017)
Journal Article
Hekking, P., Loza, M. J., Pavlidis, S., de Meulder, B., Lefaudeux, D., Baribaud, F., …Sterk, P. J. (2018). Pathway discovery using transcriptomic profiles in adult-onset severe asthma. Journal of Allergy and Clinical Immunology, 141(4), 1280-1290. https://doi.org/10.1016/j.jaci.2017.06.037

Background: Adult-onset severe asthma is characterized by highly symptomatic disease despite high-intensity asthma treatments. Understanding of the underlying pathways of this heterogeneous disease is needed for the development of targeted treatments... Read More about Pathway discovery using transcriptomic profiles in adult-onset severe asthma.

Comparable reductions in hyperpnoea-induced bronchoconstriction and markers of airway inflammation after supplementation with 6·2 and 3·1 g/d of long-chain n-3 PUFA in adults with asthma (2017)
Journal Article
Williams, N. C., Hunter, K. A., Shaw, D. E., Jackson, K. G., Sharpe, G. R., & Johnson, M. A. (2017). Comparable reductions in hyperpnoea-induced bronchoconstriction and markers of airway inflammation after supplementation with 6·2 and 3·1 g/d of long-chain n-3 PUFA in adults with asthma. British Journal of Nutrition, 117(10), https://doi.org/10.1017/S0007114517001246

Although high dose n-3 PUFA supplementation reduces exercise- and hyperpnoea-induced bronchoconstriction (EIB/HIB), there are concurrent issues with cost, compliance and gastrointestinal discomfort. It is thus pertinent to establish the efficacy of l... Read More about Comparable reductions in hyperpnoea-induced bronchoconstriction and markers of airway inflammation after supplementation with 6·2 and 3·1 g/d of long-chain n-3 PUFA in adults with asthma.

Beta-agonist overuse and delay in obtaining medical review in high risk asthma: a secondary analysis of data from a randomised controlled trial (2017)
Journal Article
Pilcher, J., Patel, M., Pritchard, A., Thayabaran, D., Ebmeier, S., Shaw, D., …Beasley, R. (2017). Beta-agonist overuse and delay in obtaining medical review in high risk asthma: a secondary analysis of data from a randomised controlled trial. npj Primary Care Respiratory Medicine, 27(1), https://doi.org/10.1038/s41533-017-0032-z

Asthma mortality surveys report delays in seeking medical review and overuse of beta-agonist therapy as factors contributing to a fatal outcome. However, the strength of these associations is limited because many asthma deaths are unwitnessed. We und... Read More about Beta-agonist overuse and delay in obtaining medical review in high risk asthma: a secondary analysis of data from a randomised controlled trial.

Predicting hospital stay, mortality and readmission in people admitted for hypoglycaemia: prognostic models derivation and validation (2017)
Journal Article
Zaccardi, F., Webb, D. R., Davies, M. J., Dhalwani, N. N., Gray, L. J., Chatterjee, S., …Khunti, K. (2017). Predicting hospital stay, mortality and readmission in people admitted for hypoglycaemia: prognostic models derivation and validation. Diabetologia, 60(6), 1007-1015. https://doi.org/10.1007/s00125-017-4235-1

Aims/hypothesis: Hospital admissions for hypoglycaemia represent a significant burden on individuals with diabetes and have a substantial economic impact on healthcare systems. To date, no prognostic models have been developed to predict outcomes fol... Read More about Predicting hospital stay, mortality and readmission in people admitted for hypoglycaemia: prognostic models derivation and validation.

Risk factors and outcome differences in hypoglycaemia-related hospital admissions: A case-control study in England: ZACCARDIet al. (2017)
Journal Article
Zaccardi, F., Webb, D. R., Davies, M. J., Dhalwani, N. N., Housley, G., Shaw, D., …Khunti, K. (2017). Risk factors and outcome differences in hypoglycaemia-related hospital admissions: A case-control study in England: ZACCARDIet al. Diabetes, Obesity and Metabolism, 19(10), 1371-1378. https://doi.org/10.1111/dom.12941

Aims: To evaluate risk factors for hospital admissions for hypoglycaemia and compare length of hospitalization, inpatient mortality and hospital readmission between hypoglycaemia- and nonhypoglycaemia-related admissions. Materials and methods: We us... Read More about Risk factors and outcome differences in hypoglycaemia-related hospital admissions: A case-control study in England: ZACCARDIet al..