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Comparable reductions in hyperpnoea-induced bronchoconstriction and markers of airway inflammation after supplementation with 6·2 and 3·1 g/d of long-chain n-3 PUFA in adults with asthma

Williams, Neil C.; Hunter, Kirsty A.; Shaw, Dominick E.; Jackson, Kim G.; Sharpe, Graham R.; Johnson, Michael A.

Authors

Neil C. Williams

Kirsty A. Hunter

Dominick E. Shaw

Kim G. Jackson

Graham R. Sharpe

Michael A. Johnson



Abstract

Although high dose n-3 PUFA supplementation reduces exercise- and hyperpnoea-induced bronchoconstriction (EIB/HIB), there are concurrent issues with cost, compliance and gastrointestinal discomfort. It is thus pertinent to establish the efficacy of lower n-3 PUFA doses. Eight male adults with asthma and HIB and eight controls without asthma were randomly supplemented with two n-3 PUFA doses (6·2 g/d (3·7 g EPA and 2·5 g DHA) and 3·1 g/d (1·8 g EPA and 1·3 g DHA)) and a placebo, each for 21 d followed by 14 d washout. A eucapnic voluntary hyperpnoea (EVH) challenge was performed before and after treatments. Outcome measures remained unchanged in the control group. In the HIB group, the peak fall in forced expiratory volume in 1 s (FEV1) after EVH at day 0 (−1005 (sd 520) ml, −30 (sd 18) %) was unchanged after placebo. The peak fall in FEV1 was similarly reduced from day 0 to day 21 of 6·2 g/d n-3 PUFA (−1000 (sd 460) ml, −29 (sd 17) % v. −690 (sd 460) ml, −20 (sd 15) %) and 3·1 g/d n-3 PUFA (−970 (sd 480) ml, −28 (sd 18) % v. −700 (sd 420) ml, −21 (sd 15) %) (P

Journal Article Type Article
Publication Date May 28, 2017
Journal British Journal of Nutrition
Print ISSN 0007-1145
Electronic ISSN 1475-2662
Publisher Cambridge University Press (CUP)
Peer Reviewed Peer Reviewed
Volume 117
Issue 10
APA6 Citation Williams, N. C., Hunter, K. A., Shaw, D. E., Jackson, K. G., Sharpe, G. R., & Johnson, M. A. (2017). Comparable reductions in hyperpnoea-induced bronchoconstriction and markers of airway inflammation after supplementation with 6·2 and 3·1 g/d of long-chain n-3 PUFA in adults with asthma. British Journal of Nutrition, 117(10), doi:10.1017/S0007114517001246
DOI https://doi.org/10.1017/S0007114517001246
Keywords n-3 PUFA; Asthma; Exercise; Inflammation
Publisher URL https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/comparable-reductions-in-hyperpnoeainduced-bronchoconstriction-and-markers-of-airway-inflammation-after-supplementation-with-62-and-31-gd-of-longchain-n3-pufa-in-adults-with-asth
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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comparable_reductions_in_hyperpnoeainduced_bronchoconstriction_and_markers_of_airway_inflammation_after_supplementation_with_62_and_31_gd_of_longchain_n3_pufa_in_adults_with_asthma.pdf (1.5 Mb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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