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A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics (2019)
Journal Article
Bradley, C. R., Bragg, D. D., Cox, E. F., El-Sharkawy, A. M., Buchanan, C. E., Chowdhury, A. H., …Lobo, D. N. (2020). A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics. Clinical Nutrition, 39(7), 2070-2079. https://doi.org/10.1016/j.clnu.2019.09.011

Background & aims Blood volume expanding properties of colloids are superior to crystalloids. In addition to oncotic/osmotic properties, the electrolyte composition of infusions may have important effects on visceral perfusion, with infusions contai... Read More about A randomized, controlled, double-blind crossover study on the effects of isoeffective and isovolumetric intravenous crystalloid and gelatin on blood volume, and renal and cardiac hemodynamics.

Modulation of T regulatory and dendritic cell phenotypes following ingestion of Bifidobacterium longum, active hexose correlated compound (AHCC®) and azithromycin in healthy individuals (2019)
Journal Article
Chowdhury, A. H., Cámara, M., Verma, C., Eremin, O., Kulkarni, A. D., & Lobo, D. N. (2019). Modulation of T regulatory and dendritic cell phenotypes following ingestion of Bifidobacterium longum, active hexose correlated compound (AHCC®) and azithromycin in healthy individuals. Nutrients, 11(10), Article 2470. https://doi.org/10.3390/nu11102470

The probiotic Bifidus BB536 (BB536), which contains Bifidobacterium longum, has been shown to have enhanced probiotic effects when given together with a standardized extract of cultured Lentinula edodes mycelia (AHCC®, Amino Up Co. Ltd., Sapporo, Jap... Read More about Modulation of T regulatory and dendritic cell phenotypes following ingestion of Bifidobacterium longum, active hexose correlated compound (AHCC®) and azithromycin in healthy individuals.

Computer Tomography-Based Psoas Skeletal Muscle Area and Radiodensity are Poor Sentinels for Whole L3 Skeletal Muscle Values (2019)
Journal Article
Rollins, K. E., Gopinath, A., Awwad, A., Macdonald, I. A., & Lobo, D. N. (2020). Computer Tomography-Based Psoas Skeletal Muscle Area and Radiodensity are Poor Sentinels for Whole L3 Skeletal Muscle Values. Clinical Nutrition, 39(7), 2227-2232. https://doi.org/10.1016/j.clnu.2019.10.003

Background and aims Computed tomography (CT)-based measurement of skeletal muscle cross-sectional area (CSA) and Hounsfield unit (HU) radiodensity are used to assess the presence of sarcopenia and myosteatosis, respectively. The validated CT-based t... Read More about Computer Tomography-Based Psoas Skeletal Muscle Area and Radiodensity are Poor Sentinels for Whole L3 Skeletal Muscle Values.

Outcomes Following an Index Emergency Admission With Cholecystitis: A National Cohort Study (2019)
Journal Article
Mytton, J., Daliya, P., Singh, P., Parsons, S., Lobo, D., Lilford, R., & Vohra, R. (2021). Outcomes Following an Index Emergency Admission With Cholecystitis: A National Cohort Study. Annals of Surgery, 274(2), 367-374. https://doi.org/10.1097/SLA.0000000000003599

Objective: The objective of this study was to evaluate the differences between patients who undergo cholecystectomy following index admission for cholecystitis, and those who are managed nonoperatively. Summary Background Data: Index emergency... Read More about Outcomes Following an Index Emergency Admission With Cholecystitis: A National Cohort Study.

IgG4 Expression Correlates with Poor Prognosis in Pancreatic Adenocarcinoma (2019)
Conference Proceeding
Budd, W., Mukherjee, A., Lobo, D., & Zaitoun, A. (2019). IgG4 Expression Correlates with Poor Prognosis in Pancreatic Adenocarcinoma. In Supplement: Leeds Pathology 2019. 12th Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain & Ireland, 2–4 July 2019 (S1-S59). https://doi.org/10.1002/path.5345

Purpose of the study: IgG4, a member of the immunoglobulin family, has been implicated in the pathobiology of inflammatory disease (including autoimmune pancreatitis) and cancers. Its role in pancreatic cancers however remains to be elucidated. This... Read More about IgG4 Expression Correlates with Poor Prognosis in Pancreatic Adenocarcinoma.

Winter cancellations of elective surgical procedures in the United Kingdom: A questionnaire survey of patients on the economic and psychological impact (2019)
Journal Article
Herrod, P., Adimah, A., Boyd-Carson, H., Daliya, P., El-Sharkawy, A., Sarmah, P., …Lobo, D. (2019). Winter cancellations of elective surgical procedures in the United Kingdom: A questionnaire survey of patients on the economic and psychological impact. BMJ Open, 9, Article e028753. https://doi.org/10.1136/bmjopen-2018-028753

Objectives: To quantify the economic and psychological impact of the cancellation of operations due to winter pressures on patients, their families and the economy. Design: This questionnaire study was designed with the help of patient groups. Dat... Read More about Winter cancellations of elective surgical procedures in the United Kingdom: A questionnaire survey of patients on the economic and psychological impact.

Winter cancellations of elective surgical procedures in the UK: a questionnaire survey of patients on the economic and psychological impact (2019)
Journal Article
Herrod, P. J. J., Adiamah, A., Boyd-Carson, H., Daliya, P., El-Sharkawy, A. M., Sarmah, P. B., …Lobo, D. N. (2019). Winter cancellations of elective surgical procedures in the UK: a questionnaire survey of patients on the economic and psychological impact. BMJ Open, 9(9), 1-8. https://doi.org/10.1136/bmjopen-2018-028753

Objectives To quantify the economic and psychological impact of the cancellation of operations due to winter pressures on patients, their families and the economy. Design This questionnaire study was designed with the help of patient groups. Data... Read More about Winter cancellations of elective surgical procedures in the UK: a questionnaire survey of patients on the economic and psychological impact.

Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials (2019)
Journal Article
Chowdhury, A., Adiamah, A., Kushairi, A., Varadhan, K. K., Krznaric, Z., Kulkarni, A. D., …Lobo, D. N. (2020). Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Annals of Surgery, 271(6), 1036-1047. https://doi.org/10.1097/sla.0000000000003581

This meta-analysis of 34 randomized controlled trials reporting on 2723 participants has shown that perioperative administration of either probiotics or synbiotics was well tolerated and significantly reduced the risk of infectious complications foll... Read More about Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Thioredoxin system protein expression in carcinomas of the pancreas, bile duct and ampulla (2019)
Working Paper
Al-hadyan, K., Storr, S., Zaitoun, A., Lobo, D., & Martin, S. Thioredoxin system protein expression in carcinomas of the pancreas, bile duct and ampulla

Background: Pancreatic cancer (PC), including the ampulla and bile duct, is very aggressive, and thus difficult to treat with effective therapies. The current treatment options have failed to improve PC five-year survival rates over the last 30 to 40... Read More about Thioredoxin system protein expression in carcinomas of the pancreas, bile duct and ampulla.

Meta-analysis of goal directed fluid therapy using transoesophageal doppler in patients undergoing elective colorectal surgery (2019)
Journal Article
Rollins, K., Mathias, N., & Lobo, D. (2019). Meta-analysis of goal directed fluid therapy using transoesophageal doppler in patients undergoing elective colorectal surgery. BJS Open, 3(5), 606-616. https://doi.org/10.1002/bjs5.50188

Background: Intraoperative goal-directed fluid therapy (GDFT) is recommended for intraoperative fluid management for elective colorectal surgery in most perioperative guidelines. However, the evidence in elective colorectal surgery alone is not welle... Read More about Meta-analysis of goal directed fluid therapy using transoesophageal doppler in patients undergoing elective colorectal surgery.

A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy (2019)
Journal Article
Daliya, P., Gemmill, E. H., Lobo, D. N., & Parsons, S. L. (2019). A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy. Hepatobiliary Surgery and Nutrition, 8(3), 228-245. https://doi.org/10.21037/hbsn.2019.03.16

Background Patient Reported Outcome Measures (PROMs) provide a valuable means of measuring outcomes subjectively from a patient's perspective, facilitating the assessment of service quality across healthcare providers, and assisting patients and clin... Read More about A systematic review of patient reported outcome measures (PROMs) and quality of life reporting in patients undergoing laparoscopic cholecystectomy.

Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28 (2019)
Journal Article
Levy, N., Lobo, D. N., Fawcett, W. J., Ljungqvist, O., & Scott, M. J. (2019). Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28. British Journal of Anaesthesia, 22(6), e215–e216. https://doi.org/10.1016/j.bja.2019.01.028

We read with interest the special and insightful article by Soffin and colleagues1 on the prescription opioid crisis. They carefully examine many of the drivers for subsequent opioid dependence after surgery and provide suggestions on how practice ca... Read More about Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28.

The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis (2019)
Journal Article
Adiamah, A., Skořepa, P., Weimann, A., & Lobo, D. N. (2019). The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis. Annals of Surgery, 270(2), 247-246. https://doi.org/10.1097/SLA.0000000000003256

Objective: To define the influence of preoperative immune modulating nutrition (IMN) on postoperative outcomes in patients undergoing surgery for gastrointestinal cancer. Summary background data: Although studies have shown that perioperative IMN... Read More about The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis.

The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective (2019)
Journal Article
Allison, S. P., & Lobo, D. N. (2020). The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective. Clinical Nutrition, 39(1), 304-305. https://doi.org/10.1016/j.clnu.2019.01.027

Many theories have been advanced concerning the cause of Charlotte Bronte’s death, none of which fully explain all the symptoms she experienced in the course of her final illness. Her death certificate records the cause of death as phthisis (tubercul... Read More about The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective.

The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig (2019)
Journal Article
Hammond, J. S., Godtliebsen, F., Steigen, S., Guha, I. N., Wyatt, J., Revhaug, A., …Mortensen, K. E. (2019). The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig. Clinical Science, 133(1), 153-166. https://doi.org/10.1042/CS20180858

Liver failure is the major cause of death following liver resection. Post-resection portal venous pressure (PVP) predicts liver failure, is implicated in its pathogenesis and when PVP is reduced, rates of liver dysfunction decrease. The aim of this s... Read More about The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig.

The role of oral antibiotic preparation in elective colorectal surgery: a meta-analysis (2018)
Journal Article
Rollins, K. E., Javanmard-Emamghissi, H., Acheson, A. G., & Lobo, D. N. (2019). The role of oral antibiotic preparation in elective colorectal surgery: a meta-analysis. Annals of Surgery, 270(1), 43-58. https://doi.org/10.1097/SLA.0000000000003145

© 2018 The Author(s). Published by Wolters Kluwer Health, Inc. Objectives:To compare the impact of the use of oral antibiotics (OAB) with or without mechanical bowel preparation (MBP) on outcome in elective colorectal surgery.Summary Background Data:... Read More about The role of oral antibiotic preparation in elective colorectal surgery: a meta-analysis.

Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018 (2018)
Journal Article
Gustafsson, U. O., Scott, M. J., Hubner, M., Nygren, J., Demartines, N., Francis, N., …Ljungqvist, O. (2019). Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018. World Journal of Surgery, 43(3), 659-695. https://doi.org/10.1007/s00268-018-4844-y

Background: This is the fourth updated Enhanced Recovery After Surgery (ERAS®) Society guideline presenting a consensus for optimal perioperative care in colorectal surgery and providing graded recommendations for each ERAS item within the ERAS® prot... Read More about Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018.

Intestinal failure in adults: recommendations from the ESPEN Expert Groups (2018)
Journal Article
Pironi, L., Corcos, O., Forbes, A., Holst, M., Joly, F., Jonkers, C., …ESPEN Acute and Chronic Intestinal Failure Special Interest Groups. (2018). Intestinal failure in adults: recommendations from the ESPEN Expert Groups. Clinical Nutrition, 36(6A), 1798-1809. https://doi.org/10.1016/j.clnu.2018.07.036

Background and aims: Intestinal failure (IF) is defined as “the reduction of gut function below the minimum necessary for the absorption of macronutrients and/or water and electrolytes, such that intravenous supplementation is required to maintain h... Read More about Intestinal failure in adults: recommendations from the ESPEN Expert Groups.