Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Chowdhury, Abeed; Adiamah, Alfred; Kushairi, Anisa; Varadhan, Krishna K.; Krznaric, Zeljko; Kulkarni, Anil D.; Neal, Keith; Lobo, Dileep N.

Abstract

This meta-analysis of 34 randomized controlled trials reporting on 2723 participants has shown that perioperative administration of either probiotics or synbiotics was well tolerated and significantly reduced the risk of infectious complications following elective abdominal surgery. However, there were no differences in non-infectious complications or mortality between the intervention and control groups.

Citation

Chowdhury, A., Adiamah, A., Kushairi, A., Varadhan, K. K., Krznaric, Z., Kulkarni, A. D., …Lobo, D. N. (2020). Perioperative Probiotics or Synbiotics in Adults Undergoing Elective Abdominal Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Annals of Surgery, 271(6), 1036-1047. https://doi.org/10.1097/sla.0000000000003581

• Journal Article Type: Article
• Acceptance Date: Aug 5, 2019
• Online Publication Date: Aug 28, 2019
• Publication Date: 2020-06
• Deposit Date: Aug 8, 2019
• Publicly Available Date: Sep 4, 2019
• Journal: Annals of Surgery
• Print ISSN: 0003-4932
• Electronic ISSN: 1528-1140
• Publisher: Lippincott, Williams & Wilkins
• Peer Reviewed: Peer Reviewed
• Volume: 271
• Issue: 6
• Pages: 1036-1047
• DOI: https://doi.org/10.1097/sla.0000000000003581
• Keywords: Probiotics; Synbiotics; Elective abdominal surgery; Outcomes; Meta-analysis
• Public URL: https://nottingham-repository.worktribe.com/output/2406406
• Publisher URL: https://insights.ovid.com/crossref?an=00000658-900000000-94930