All Outputs (155)

Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids (2022)
Journal Article

Little is known about the role of microRNAs (miRNAs) in rewiring the metabolism within tumours and adjacent non-tumour bearing normal tissue and their potential in cancer therapy. This study aimed to investigate the relationship between deregulated m... Read More about Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids.

Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review (2022)
Journal Article

Background: We aimed to appraise the evidence relating to the measurement properties of unidimensional tools to quantify pain after surgery. Furthermore, we wished to identify the tools used to assess interference of pain with functional recovery. Me... Read More about Utility of unidimensional and functional pain assessment tools in adult postoperative patients: a systematic review.

Current Issues in the Use of Opioids for the Management of Postoperative Pain: A Review (2021)
Journal Article

Importance: Uncontrolled and indiscriminate prescribing of opioids has led to an opioid crisis that started in North America and spread throughout high-income countries. The aim of this narrative review was to explore some of the current issues surro... Read More about Current Issues in the Use of Opioids for the Management of Postoperative Pain: A Review.

The importance of protein sources to support muscle anabolism in cancer: An expert group opinion (2021)
Journal Article

This opinion paper presents a short review of the potential impact of protein on muscle anabolism in cancer, which is associated with better patient outcomes. Protein source is a topic of interest for patients and clinicians, partly due to recent emp... Read More about The importance of protein sources to support muscle anabolism in cancer: An expert group opinion.

Response to Igor Eckert: Sometimes, the absence of evidence is evidence of its absence (2021)
Journal Article

Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort Study (2021)
Journal Article

Background: Surgeon burnout has implications for patient safety and workforce sustainability. The aim of this study was to establish the prevalence of burnout among surgeons in the UK during the COVID-19 pandemic. Methods: This cross-sectional on... Read More about Burnout Among Surgeons in the UK During the COVID-19 Pandemic: A Cohort Study.

Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered? (2021)
Journal Article

Rosenberg and colleagues1 first proposed the use of nonabsorbable oral antibiotic preparation (OAB) for colorectal surgery in 1971. In a randomized clinical trial, they demonstrated a reduction in surgical site infection and anastomotic leak rates af... Read More about Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered?.

Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta-analysis (2021)
Journal Article

Background and Aim: This meta-analysis aimed to estimate the incidence of splanchnic vein thrombosis (SVT) in patients with acute pancreatitis and assess the effects of therapeutic anticoagulation. Methods: Systematic searches of the Medline, Embase,... Read More about Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta-analysis.

Management of disease-related malnutrition for patients being treated in hospital (2021)
Journal Article

Disease-related malnutrition in adult patients who have been admitted to hospital is a syndrome associated with substantially increased morbidity, disability, short-term and long-term mortality, impaired recovery from illness, and cost of care. There... Read More about Management of disease-related malnutrition for patients being treated in hospital.

Postoperative arginine-enriched immune modulating nutrition: Long-term survival results from a randomised clinical trial in patients with oesophagogastric and pancreaticobiliary cancer (2021)
Journal Article

Background & aims: Immune modulating nutrition (IMN) has been shown to reduce postoperative infectious complications and length of stay in patients with gastrointestinal cancer. Two studies of IMN in patients undergoing surgery for head and neck canc... Read More about Postoperative arginine-enriched immune modulating nutrition: Long-term survival results from a randomised clinical trial in patients with oesophagogastric and pancreaticobiliary cancer.

Immunohistochemical inflammation in histologically normal appendices in patients with right iliac fossa pain (2021)
Journal Article

Background Histologically normal appendices resected for right iliac fossa pain in children demonstrate immunohistochemical markers of inflammation. We aimed to establish if subclinical inflammation was present in histologically normal appendices re... Read More about Immunohistochemical inflammation in histologically normal appendices in patients with right iliac fossa pain.

Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020 (2021)
Journal Article

Background: Presentation at academic conferences is an important marker of research productivity. However, not all accepted abstracts progress to full publication, and there is anecdotal evidence suggesting an imbalance in sex and ethnicity amongst p... Read More about Publication Rates, Ethnic and Sex Disparities in UK and Ireland Surgical Research Prize Presentations: An Analysis of Data From the Moynihan and Patey Prizes From 2000 to 2020.

Perioperative Opioids - Reclaiming Lost Ground (2021)
Journal Article

Opium (poppy tears) has been in use since 3400 BCE, with historical writings recording its sedative, euphoric, and analgesic properties, but it was not until the 19th century that morphine was isolated, paving the way for its therapeutic use. The 20t... Read More about Perioperative Opioids - Reclaiming Lost Ground.

Preoperative opioid use: a modifiable risk factor for poor postoperative outcomes (2021)
Journal Article

De-implementation of extended-release opioids from peri-operative pathways (2021)
Journal Article

Opportunities and Challenges for the Next Phase of Enhanced Recovery After Surgery: A Review (2021)
Journal Article

Importance: Enhanced Recovery After Surgery (ERAS) is a global surgical quality improvement initiative now firmly entrenched within the field of perioperative care. Although ERAS is associated with significant clinical outcome improvements and cost... Read More about Opportunities and Challenges for the Next Phase of Enhanced Recovery After Surgery: A Review.

ESPEN practical guideline: Clinical nutrition in surgery (2021)
Journal Article

Early oral feeding is the preferred mode of nutrition for surgical patients. Avoidance of any nutritional therapy bears the risk of underfeeding during the postoperative course after major surgery. Considering that malnutrition and underfeeding are r... Read More about ESPEN practical guideline: Clinical nutrition in surgery.

Opioid prescription at postoperative discharge: a retrospective observational cohort study (2021)
Journal Article

Opioid misuse is now considered a major public health epidemic in North America, with substantial social and financial consequences. As well as socio-economic and commercial drivers, modifiable risk-factors that have resulted in this crisis have been... Read More about Opioid prescription at postoperative discharge: a retrospective observational cohort study.

Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization (2021)
Journal Article

Background Enhanced Recovery After Surgery (ERAS) protocols reduce length of stay, complications and costs fora large number of elective surgical procedures. A similar, structured approach appears to improve outcomes, including mortality, for patien... Read More about Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS) Society Recommendations: Part 1—Preoperative: Diagnosis, Rapid Assessment and Optimization.

Regional anaesthesia and persistent postoperative opioid use: a reply (2021)
Journal Article