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All Outputs (97)

Epidemiology and risk factors of osteosarcoma (2020)
Journal Article
Sadykova, L. R., Ntekim, A. I., Muyangwa-Semenova, M., Rutland, C. S., Jeyapalan, J. N., Blatt, N., & Rizvanov, A. (2020). Epidemiology and risk factors of osteosarcoma. Cancer Investigation, 38(5), 259-269. https://doi.org/10.1080/07357907.2020.1768401

Osteosarcoma is a rare tumor diagnosed at any age; however younger age is a common risk factor. In addition, multiple factors are believed to contribute to higher rates of osteosarcoma, particularly race and gender. Although diagnosed worldwide, oste... Read More about Epidemiology and risk factors of osteosarcoma.

Cell Culture Based in vitro Test Systems for Anticancer Drug Screening (2020)
Journal Article
Solovyeva, V. V., Kitaeva, K. V., Rutland, C. S., & Rizvanov, A. A. (2020). Cell Culture Based in vitro Test Systems for Anticancer Drug Screening. Frontiers in Bioengineering and Biotechnology, 8, Article 322. https://doi.org/10.3389/fbioe.2020.00322

The development of new high-tech systems for screening anticancer drugs is one of the main problems of preclinical screening. Poor correlation between preclinical in vitro and in vivo data with clinical trials remains a major concern. The choice of t... Read More about Cell Culture Based in vitro Test Systems for Anticancer Drug Screening.

Morphological and imaging evaluation of the metacarpophalangeal and metatarsophalangeal joints in healthy and lame donkeys (2019)
Journal Article
El-Gendy, S. A., Alsafy, M. A., Rutland, C. S., EL-Khamary, A. N., Abu-Ahmed, H. M., & El-Kammar, M. H. (2020). Morphological and imaging evaluation of the metacarpophalangeal and metatarsophalangeal joints in healthy and lame donkeys. Journal of Equine Veterinary Science, 88, Article 102904. https://doi.org/10.1016/j.jevs.2019.102904

The donkey is of socio-economic value yet imaging techniques in both healthy and abnormal limbs are a limiting factor in research and medicine. The objective was to determine anatomical features of both healthy and clinically abnormal donkey metacarp... Read More about Morphological and imaging evaluation of the metacarpophalangeal and metatarsophalangeal joints in healthy and lame donkeys.

Production and Application of Multicistronic Constructs for Various Human Disease Therapies (2019)
Journal Article
Shaimardanova, A. A., Kitaeva, K. V., Abdrakhmanova, I. I., Chernov, V. M., Rutland, C. S., Rizvanov, A. A., …Solovyeva, V. V. (2019). Production and Application of Multicistronic Constructs for Various Human Disease Therapies. Pharmaceutics, 11, 580. https://doi.org/10.3390/pharmaceutics11110580

The development of multicistronic vectors has opened up new opportunities to address the fundamental issues of molecular and cellular biology related to the need for the simultaneous delivery and joint expression of several genes. To date, the exampl... Read More about Production and Application of Multicistronic Constructs for Various Human Disease Therapies.

Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo (2019)
Journal Article
Faidra Angelerou, M. G., Markus, R., Paraskevopoulou, V., Foralosso, R., Clarke, P., Alvarez, C. V., …Marlow, M. (2020). Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo. Journal of Controlled Release, 317, 118-129. https://doi.org/10.1016/j.jconrel.2019.10.011

Supramolecular gels have recently emerged as promising biomaterials for the delivery of a wide range of bioactive molecules, from small hydrophobic drugs to large biomolecules such as proteins. Although it has been demonstrated that each encapsulated... Read More about Mechanistic investigations into the encapsulation and release of small molecules and proteins from a supramolecular nucleoside gel in vitro and in vivo.

Potential therapeutic application of mesenchymal stem cells in ophthalmology (2019)
Journal Article
Zakirova, E. Y., Valeeva, A., Aimaletdinov, A., Nefedovskaya, L., Akhmetshin, R., Rutland, C., & Rizvanov, A. (2019). Potential therapeutic application of mesenchymal stem cells in ophthalmology. Experimental Eye Research, 189, Article 107863. https://doi.org/10.1016/j.exer.2019.107863

At present a wide variety of methods have been proposed to treat eye disorders, drug therapies are most commonly used. It should be noted that effective treatment modalities especially for degeneration of the retina and optic nerve are lacking. In th... Read More about Potential therapeutic application of mesenchymal stem cells in ophthalmology.

Physics of animal health: on the mechano-biology of hoof growth and form (2019)
Journal Article
Al-Agele, R., Paul, E., Taylor, S., Watson, C., Sturrock, C., Drakopoulos, M., …Rauch, C. (2019). Physics of animal health: on the mechano-biology of hoof growth and form. Interface, 16(155), 1-12. https://doi.org/10.1098/rsif.2019.0214

Global inequalities in economic access and agriculture productivity imply that a large number of developing countries rely on working equids for transport/agriculture/mining. Therefore, the understanding of hoof conditions/shape variations affecting... Read More about Physics of animal health: on the mechano-biology of hoof growth and form.

Use of biologically active 3D matrix for extensive skin defect treatment in veterinary practice: case report (2019)
Journal Article
Zakirova, E. Y., Shalimov, D. V., Garanina, E. E., Zhuravleva, M. N., Rutland, C. S., & Rizvanov, A. A. (2019). Use of biologically active 3D matrix for extensive skin defect treatment in veterinary practice: case report. Frontiers in Veterinary Science, 6, Article 76. https://doi.org/10.3389/fvets.2019.00076

Objectives: Large full-thickness skin defects represent a serious veterinary problem. Methods: We have developed novel bioactive 3D-matrixes based on fibrin glue Tissucol (Baxter), containing the combination of the adenoviral constructs with genes v... Read More about Use of biologically active 3D matrix for extensive skin defect treatment in veterinary practice: case report.

Reptilian skin and its special histological structures (2019)
Book Chapter
Rutland, C. S., Cigler, P., & Kubale Dvojmoč, V. (2019). Reptilian skin and its special histological structures. In C. S. Rutland, & V. Kubale Dvojmoč (Eds.), Veterinary anatomy and physiology (1-21). InTech. https://doi.org/10.5772/intechopen.84212

Reptilian skin is covered with scales forming armor that makes it watertight and enables reptiles to live on land in contrast to amphibians. An important part of the skin is the horny epidermis, with thick stratum corneum in which waxes are arranged... Read More about Reptilian skin and its special histological structures.

Veterinary anatomy and physiology (2019)
Book
Rutland, C. S., & Kubale Dvojmoč, V. (Eds.). (2019). Veterinary anatomy and physiology. InTech

Knowledge of veterinary anatomy and physiology is essential for veterinary professionals and researchers. The chapters reflect the diverse and dynamic research being undertaken in a variety of different species throughout the world. Whether the anima... Read More about Veterinary anatomy and physiology.

Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment (2019)
Journal Article
Al-Mayahy, M. H., Sabri, A. H., Rutland, C. S., Holmes, A., McKenna, J., Marlow, M., & Scurr, D. J. (2019). Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment. European Journal of Pharmaceutics and Biopharmaceutics, 139, 33-43. https://doi.org/10.1016/j.ejpb.2019.02.006

Basal cell carcinoma (BCC) is the most common skin cancer in humans. Topical treatment with imiquimod provides a non-invasive, self-administered treatment with relatively low treatment cost. Despite displaying excellent efficacy, imiquimod is only li... Read More about Insight into imiquimod skin permeation and increased delivery using microneedle pre-treatment.

The Anatomy, Histology and Physiology of the Healthy and Lame Equine Hoof (2019)
Book Chapter
Al-Agele, R., Paul, E., Kubale Dvojmoc, V., Sturrock, C. J., Rauch, C., & Rutland, C. S. (2019). The Anatomy, Histology and Physiology of the Healthy and Lame Equine Hoof. In Veterinary Anatomy and Physiology. IntechOpen. https://doi.org/10.5772/intechopen.84514

Satisfactory investigations of the equine foot appear to be limited by the histomorphological complexity of internal hoof structures. Foot lameness is considered to be one of the most debilitating pathological disorders of the equine foot. In most sp... Read More about The Anatomy, Histology and Physiology of the Healthy and Lame Equine Hoof.

Avian Cardiovascular Disease Characteristics, Causes and Genomics (2018)
Book Chapter
Kubale, V., Merry, K., Miller, G., Ruiz Diaz, M., & Rutland, C. (2018). Avian Cardiovascular Disease Characteristics, Causes and Genomics. In X. Liu (Ed.), Application of genetics and genomics in poultry science (141-162). London: InTech. https://doi.org/10.5772/intechopen.78005

Cardiovascular disease is common in avian species and increasing commercial economic losses and demand for healthcare in the household/smallholding veterinary sector has resulted in increased research into these disorders. This in turn has highlighte... Read More about Avian Cardiovascular Disease Characteristics, Causes and Genomics.

Gene therapy using plasmid DNA encoding VEGF164 and FGF2 genes: a novel treatment of naturally occurring tendinitis and desmitis in horses (2018)
Journal Article
Kovac, M., Litvin, Y. A., Aliev, R. O., Zakirova, E. Y., Rutland, C. S., Kiyasov, A. P., & Rizvanov, A. A. (2018). Gene therapy using plasmid DNA encoding VEGF164 and FGF2 genes: a novel treatment of naturally occurring tendinitis and desmitis in horses. Frontiers in Pharmacology, 9, https://doi.org/10.3389/fphar.2018.00978

This clinical study describes the intralesional application of the plasmid DNA encoding two therapeutic species-specific growth factors: vascular endothelial growth factor (VEGF164) and fibroblast growth factor 2 (FGF2) in seven horses to restore nat... Read More about Gene therapy using plasmid DNA encoding VEGF164 and FGF2 genes: a novel treatment of naturally occurring tendinitis and desmitis in horses.

Mending a broken heart—the genetics of heart disease (2018)
Journal Article
Clark, N., Alibhai, A., & Rutland, C. S. (2018). Mending a broken heart—the genetics of heart disease. Frontiers for Young Minds, 6, Article 19. https://doi.org/10.3389/frym.2018.00019

Heart disease is a major cause of health problems worldwide. There are many different types of heart disease, but one that is fairly common and can have lots of negative side effects is called cardiomyopathy. We know that humans and many mammals, inc... Read More about Mending a broken heart—the genetics of heart disease.

Peri-conception and first trimester diet modifies reproductive development in bulls (2017)
Journal Article
Copping, K. J., Ruiz-Diaz, M. D., Rutland, C. S., Mongan, N. P., Callaghan, M., McMillen, I. C., …Perry, V. (in press). Peri-conception and first trimester diet modifies reproductive development in bulls. Reproduction, Fertility and Development, https://doi.org/10.1071/RD17102

Nutritional perturbation during gestation alters male reproductive development in rodents and sheep. In cattle both the developmental trajectory of the feto–placental unit and its response to dietary perturbations is dissimilar to that of these speci... Read More about Peri-conception and first trimester diet modifies reproductive development in bulls.

Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer (2017)
Book Chapter
Rutland, C. S., de Brot, S., James, V., & Mongan, N. P. (2018). Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer. In J. Chakrabarti, & S. Mitra (Eds.), Cancer and Noncoding RNAs (359-372). Elsevier. https://doi.org/10.1016/b978-0-12-811022-5.00019-x

In eukaryotes, the packaging of DNA and proteins, termed chromatin, is an essential determinant of transcription. The basic unit of chromatin, the nucleosome, is composed of ∼146 base pairs of DNA spooled around a dense protein core containing two co... Read More about Heterochromatin modulation and PCG control of gene expression mediated by noncoding RNA in cancer.