All Outputs (12)

Energy Metabolism in Mouse Sciatic Nerve A Fibres during Increased Energy Demand (2022)
Journal Article

The ability of sciatic nerve A fibres to conduct action potentials relies on an adequate supply of energy substrate, usually glucose, to maintain necessary ion gradients. Under our ex vivo experimental conditions, the absence of exogenously applied g... Read More about Energy Metabolism in Mouse Sciatic Nerve A Fibres during Increased Energy Demand.

Calbindin Deficits May Underlie Dissociable Effects of 5-HT6 and mGlu7 Antagonists on Glutamate and Cognition in a Dual-Hit Neurodevelopmental Model for Schizophrenia (2020)
Journal Article

© 2020, The Author(s). Despite several compounds entering clinical trials for the negative and cognitive symptoms of schizophrenia, few have progressed beyond phase III. This is partly attributed to a need for improved preclinical models, to understa... Read More about Calbindin Deficits May Underlie Dissociable Effects of 5-HT6 and mGlu7 Antagonists on Glutamate and Cognition in a Dual-Hit Neurodevelopmental Model for Schizophrenia.

A method for reducing animal use whilst maintaining statistical power in electrophysiological recordings from rodent nerves (2020)
Journal Article

The stimulus evoked compound action potential, recorded from ex vivo nerve trunks such as the rodent optic and sciatic nerve, is a popular model system used to study aspects of nervous system metabolism. This includes (1) the role of glycogen in supp... Read More about A method for reducing animal use whilst maintaining statistical power in electrophysiological recordings from rodent nerves.

Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification (2019)
Journal Article

Hypoglycemia is a common iatrogenic consequence of type 1 diabetes therapy that can lead to central nervous system injury and even death if untreated. In the absence of clinically effective neuroprotective drugs we sought to quantify the putative neu... Read More about Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification.

Flowcharts to aid student comprehension of Nernst equation calculations (2018)
Journal Article

Fibre sub-type specific conduction reveals metabolic function in mouse sciatic nerve (2018)
Journal Article

The stimulus evoked compound action potential (CAP), recorded using suction electrodes, provides an index of the relative number of conducting axons within a nerve trunk. As such the CAP has been used to elucidate the diverse mechanisms of injury res... Read More about Fibre sub-type specific conduction reveals metabolic function in mouse sciatic nerve.

Acute effect of pore-forming Clostridium perfringens ?-toxin on compound action potentials of optic nerve of mouse (2017)
Journal Article

ε-Toxin is a pore forming toxin produced by Clostridium perfringens types B and D. It is synthesized as a less active prototoxin form that becomes fully active upon proteolytic activation. The toxin produces highly lethal enterotoxaemia in ruminants,... Read More about Acute effect of pore-forming Clostridium perfringens ?-toxin on compound action potentials of optic nerve of mouse.

A lifetime’s adventure in extracellular K+ regulation: the Scottish connection (2017)
Journal Article

In a career that has spanned 45 years and shows no signs of slowing down, Dr Bruce Ransom has devoted considerable time and energy to studying regulation of interstitial K+. When Bruce commenced his studies in 1969 virtually nothing was known of the... Read More about A lifetime’s adventure in extracellular K+ regulation: the Scottish connection.

The critical role of logarithmic transformation in Nernstian equilibrium potential calculations (2017)
Journal Article

The membrane potential, arising from uneven distribution of ions across cell membranes containing selectively permeable ion channels, is of fundamental importance to cell signaling. The necessity of maintaining the membrane potential may be appreciat... Read More about The critical role of logarithmic transformation in Nernstian equilibrium potential calculations.

Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations (2014)
Journal Article

The ability to understand and implement calculations required for molarity and dilution computations that are routinely undertaken in the laboratory are essential skills that should be possessed by all students entering an undergraduate Life Sciences... Read More about Revision workshops in elementary mathematics enhance student performance in routine laboratory calculations.

Computational modeling of the effects of auditory nerve dysmyelination (2014)
Journal Article

Our previous study showed that exposure to loud sound leading to hearing loss elongated the auditory nerve (AN) nodes of Ranvier and triggered notable morphological changes at paranodes and juxtaparanodes. Here we used computational modeling to exami... Read More about Computational modeling of the effects of auditory nerve dysmyelination.

Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage (2014)
Journal Article

Objective: Hypoglycemia is a common adverse event and can injure central nervous system (CNS) white matter (WM). We determined if glutamate receptors were involved in hypoglycemic WM injury. Methods: Mouse optic nerves (MON), CNS WM tracts, were mai... Read More about Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage.