High throughput methods applied in biomaterial development and discovery

Hook, Andrew L.; Anderson, Daniel G.; Langer, Robert; Williams, Paul; Davies, Martyn C.; Alexander, Morgan R.

doi:10.1016/j.biomaterials.2009.09.037

All Outputs (45)

High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry (2013)
Journal Article

Switchable materials that alter their chemical or physical properties in response to external stimuli allow for temporal control of material-biological interactions, thus, are of interest for many biomaterial applications. Our interest is the discove... Read More about High throughput discovery of thermo-responsive materials using water contact angle measurements and time-of-flight secondary ion mass spectrometry.

Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces (2012)
Journal Article

Designing materials to control biology is an intense focus of biomaterials and regenerative medicine research. Discovering and designing materials with appropriate biological compatibility or active control of cells and tissues is being increasingly... Read More about Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces.

Combinatorial discovery of polymers resistant to bacterial attachment (2012)
Journal Article

Bacterial attachment and subsequent biofilm formation pose key challenges to the optimal performance of medical devices. In this study, we determined the attachment of selected bacterial species to hundreds of polymeric materials in a high-throughput... Read More about Combinatorial discovery of polymers resistant to bacterial attachment.

Polymers with hydro-responsive topography identi?ed using high throughput AFM of an acrylate microarray (2011)
Journal Article

Atomic force microscopy has been applied to an acrylate polymer microarray to achieve a full topographic characterisation. This process discovered a small number of hydro-responsive materials created from monomers with disparate hydrophilicities that... Read More about Polymers with hydro-responsive topography identi?ed using high throughput AFM of an acrylate microarray.

High throughput methods applied in biomaterial development and discovery (2010)
Journal Article

The high throughput discovery of new materials can be achieved by rapidly screening many different materials synthesised by a combinatorial approach to identify the optimal material that fulfils a particular biomedical application. Here we review the... Read More about High throughput methods applied in biomaterial development and discovery.