All Outputs (126)

Surgical materials: Current challenges and nano-enabled solutions (2014)
Journal Article

© 2014 Elsevier Ltd. All rights reserved. Surgical adhesive biomaterials have emerged as substitutes to sutures and staples in many clinical applications. Nano-enabled materials containing nanoparticles or having a distinct nanotopography have been u... Read More about Surgical materials: Current challenges and nano-enabled solutions.

Utilizing nanosensor-incorporated scaffolds in the development of a 3D lung model (2014)
Book Chapter

Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds (2014)
Journal Article

Human airway smooth muscle (HASM) contraction plays a central role in regulating airway resistance in both healthy and asthmatic bronchioles. In vitro studies that investigate the intricate mechanisms that regulate this contractile process are predom... Read More about Human airway smooth muscle maintain in situ cell orientation and phenotype when cultured on aligned electrospun scaffolds.

A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells (2014)
Journal Article

Conventional airway in vitro models focus upon the function of individual structural cells cultured in a two-dimensional monolayer, with limited three-dimensional (3D) models of the bronchial mucosa. Electrospinning offers an attractive method to pro... Read More about A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells.

A janus-paper PDMS platform for lab-on-a-chip applications (2014)
Conference Proceeding

© 2014TRF. A commercially available Janus paper with one hydrophobic (polyethylene-coated) face and a hygroscopic/hydrophilic one is irreversibly bonded to a PDMS substrate incorporating microfluidic channels via corona discharge surface treatment. T... Read More about A janus-paper PDMS platform for lab-on-a-chip applications.

Handbook Of Biomimetics And Bioinspiration: Biologically-driven Engineering Of Materials, Processes, Devices, And Systems (2014)
Book

Global warming, pollution, food and water shortage, cyberspace insecurity, over-population, land erosion, and an overburdened health care system are major issues facing the human race and our planet. These challenges have presented a mandate to devel... Read More about Handbook Of Biomimetics And Bioinspiration: Biologically-driven Engineering Of Materials, Processes, Devices, And Systems.

Front matter (2014)
Book Chapter

Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels (2014)
Journal Article

Fabrication of three dimensional (3D) organoids with controlled microarchitectures has been shown to enhance tissue functionality. Bioprinting can be used to precisely position cells and cell-laden materials to generate controlled tissue architecture... Read More about Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels.

Immunocompetent 3D model of human upper airway for disease modeling and in vitro drug evaluation (2014)
Journal Article

The development of more complex in vitro models for the assessment of novel drugs and chemicals is needed because of the limited biological relevance of animal models to humans as well as ethical considerations. Although some human-cell-based assays... Read More about Immunocompetent 3D model of human upper airway for disease modeling and in vitro drug evaluation.

An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells (2013)
Journal Article

Background: Allergen recognition by dendritic cells (DCs) is a key event in the allergic cascade leading to production of IgE antibodies. C-type lectins, such as the mannose receptor and DC-SIGN, were recently shown to play an important role in the u... Read More about An investigation into IgE-facilitated allergen recognition and presentation by human dendritic cells.

Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport (2013)
Journal Article

The aimof this work is to demonstrate that the structural and fluidic properties of polymer foamtissue scaffolds, post-fabrication but prior to the introduction of cells, can be engineered via exposure to high power ultrasound. Our analysis is suppor... Read More about Post-processing of polymer foam tissue scaffolds with high power ultrasound: A route to increased pore interconnectivity, pore size and fluid transport.

Self-reporting Scaffolds for 3-Dimensional Cell Culture (2013)
Journal Article

Culturing cells in 3D on appropriate scaffolds is thought to better mimic the in vivo microenvironment and increase cell-cell interactions. The resulting 3D cellular construct can often be more relevant to studying the molecular events and cell-cell... Read More about Self-reporting Scaffolds for 3-Dimensional Cell Culture.

Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells (2013)
Journal Article

Allergy is an exacerbated response of the immune system against non-self-proteins called allergens and is typically characterized by biased type-2 T helper cell and deleterious IgE mediated immune responses. The allergic cascade starts with the recog... Read More about Allergen recognition by innate immune cells: critical role of dendritic and epithelial cells.

Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution (2013)
Journal Article

This study aims to investigate interconnectivity and permeability of scCO2-foamed scaffolds and the influence of structural scaffold properties on cell distribution. Supercritical fluid technology was utilized to fabricated scaffolds from 37 kDa, 53... Read More about Interconnectivity and permeability of supercritical fluid-foamed scaffolds and the effect of their structural properties on cell distribution.

Engineering functional epithelium for regenerative medicine and in vitro organ models: A review (2013)
Journal Article

Recent advances in the fields of microfabrication, biomaterials, and tissue engineering have provided new opportunities for developing biomimetic and functional tissues with potential applications in disease modeling, drug discovery, and replacing da... Read More about Engineering functional epithelium for regenerative medicine and in vitro organ models: A review.

The development of a 3D immunocompetent model of human skin (2013)
Journal Article

As the first line of defence, skin is regularly exposed to a variety of biological, physical and chemical insults. Therefore, determining the skin sensitization potential of new chemicals is of paramount importance from the safety assessment and regu... Read More about The development of a 3D immunocompetent model of human skin.

Label-free separation and sorting of human monocytes and T-cells by electrowetting and dielectrophoresis (2013)
Conference Proceeding

We report a label-free separation and sorting approach based on electrowetting-on-dielectric (EWOD) and dielectrophoresis (DEP) to manipulate human monocyte (THP-1) and T-cell (Jurkat) lines in droplets without any impact on cell viability. In additi... Read More about Label-free separation and sorting of human monocytes and T-cells by electrowetting and dielectrophoresis.

The role of lectins in allergic sensitization and allergic disease (2013)
Journal Article

Allergic diseases are a global public health issue affecting millions of persons around the world. However, full understanding of the molecular basis of this group of chronic inflammatory disorders remains rather elusive. Recently, the role of carboh... Read More about The role of lectins in allergic sensitization and allergic disease.

Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: Self-reporting scaffolds for application in tissue engineering (2012)
Journal Article

Ratiometric analyte responsive nanosensors have been incorporated into electrospun poly(lactic-co-glycolic) acid (PLGA) fibres to create self-reporting scaffolds. It has been demonstrated that the self-reporting scaffolds could be utilised to monitor... Read More about Electrospun PLGA fibre sheets incorporating fluorescent nanosensors: Self-reporting scaffolds for application in tissue engineering.

Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release (2012)
Journal Article

Respiratory epithelial cells and macrophages are the key innate immune cells that play an important role in the pathogenesis of influenza A virus infection. We found that these two cell types from both human and pig showed comparable susceptibilities... Read More about Mammalian innate resistance to highly pathogenic avian influenza H5N1 virus infection is mediated through reduced proinflammation and infectious virus release.