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An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability (2021)
Journal Article
Wu, Y., Fortunato, G. M., Okesola, B. O., Pellerej Di Brocchetti, F. L., Suntornnond, R., Connelly, J., …Et Al, W. (2021). An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability. Biofabrication, 13(3), Article 035027. https://doi.org/10.1088/1758-5090/abe4c3

Self-assembling bioinks offer the possibility to biofabricate with molecular precision, hierarchical control, and biofunctionality. For this to become a reality with widespread impact, it is essential to engineer these ink systems ensuring reproducib... Read More about An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability.

Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model (2021)
Journal Article
Sennett, M., Friedman, J., Ashley, B., Stoeckl, B., Patel, J., Alini, M., …Dodge, G. (2021). Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model. eCells and Materials Journal, 41, 40-51. https://doi.org/10.22203/ecm.v041a04

The repair of focal cartilage defects remains one of the foremost issues in the field of orthopaedics. Chondral defects may arise from a variety of joint pathologies and left untreated, will likely progress to osteoarthritis. Current repair technique... Read More about Long term outcomes of biomaterial-mediated repair of focal cartilage defects in a large animal model.

Potential sealing and repair of human FM defects after trauma with peptide amphiphiles and Cx43 antisense (2020)
Journal Article
Barrett, D. W., Okesola, B. O., Costa, E., Thrasivoulou, C., Becker, D. L., Mata, A., …Chowdhury, T. T. (2021). Potential sealing and repair of human FM defects after trauma with peptide amphiphiles and Cx43 antisense. Prenatal Diagnosis, 41(1), 89-99. https://doi.org/10.1002/pd.5826

Objective: We examined whether peptide amphiphiles functionalised with adhesive, migratory or regenerative sequences could be combined with amniotic fluid (AF) to form plugs that repair fetal membrane (FM) defects after trauma and co-culture with con... Read More about Potential sealing and repair of human FM defects after trauma with peptide amphiphiles and Cx43 antisense.

Peptide-protein coassembling matrices as a biomimetic 3D model of ovarian cancer (2020)
Journal Article
Hedegaard, C. L., Redondo-Gómez, C., Tan, B. Y., Ng, K. W., Loessner, D., & Mata, A. (2020). Peptide-protein coassembling matrices as a biomimetic 3D model of ovarian cancer. Science Advances, 6(40), Article eabb3298. https://doi.org/10.1126/sciadv.abb3298

Bioengineered three-dimensional (3D) matrices expand our experimental repertoire to study tumor growth and progression in a biologically relevant, yet controlled, manner. Here, we used peptide amphiphiles (PAs) to coassemble with and organize extrace... Read More about Peptide-protein coassembling matrices as a biomimetic 3D model of ovarian cancer.

Host-Guest-Mediated Epitope Presentation on Self-Assembled Peptide Amphiphile Hydrogels (2020)
Journal Article
Redondo-Gómez, C., Padilla-Lopategui, S., Azevedo, H. S., & Mata, A. (2020). Host-Guest-Mediated Epitope Presentation on Self-Assembled Peptide Amphiphile Hydrogels. ACS Biomaterials Science and Engineering, 6(9), 4870–4880. https://doi.org/10.1021/acsbiomaterials.0c00549

A key feature in biomaterial design is the incorporation of bioactive signals into artificial constructs to stimulate tissue regeneration. Most currently used hydrogel cell culture systems depend on the covalent attachment of extracellular matrix (EC... Read More about Host-Guest-Mediated Epitope Presentation on Self-Assembled Peptide Amphiphile Hydrogels.

Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures (2020)
Journal Article
Majkowska, A., Redondo-Gómez, C., Rice, A., Gonzalez, M., Inostroza-Brito, K. E., Collin, E., …Mata, A. (2020). Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures. Frontiers in Materials, 7, Article 167. https://doi.org/10.3389/fmats.2020.00167

Multicomponent self-assembly holds great promise for the generation of complex and functional biomaterials with hierarchical microstructure. Here, we describe the use of supramolecular co-assembly between an elastin-like recombinamer (ELR5) and a pep... Read More about Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures.

Integrating self-assembly and biofabrication for the development of structures with enhanced complexity and hierarchical control (2020)
Journal Article
Hedegaard, C. L., & Mata, A. (2020). Integrating self-assembly and biofabrication for the development of structures with enhanced complexity and hierarchical control. Biofabrication, 12(3), https://doi.org/10.1088/1758-5090/ab84cb

Nature has evolved to grow and regenerate tissues and organs using self-assembling processes capable of organizing a wide variety of molecular building-blocks at multiple size scales. As the field of biofabrication progresses, it is essential to deve... Read More about Integrating self-assembly and biofabrication for the development of structures with enhanced complexity and hierarchical control.

Multicomponent Hydrogels for the Formation of Vascularized Bone-like Constructs In Vitro (2020)
Journal Article
Derkus, B., Okesola, B. O., Barrett, D. W., D'Este, M., Chowdhury, T. T., Eglin, D., & Mata, A. (2020). Multicomponent Hydrogels for the Formation of Vascularized Bone-like Constructs In Vitro. Acta Biomaterialia, 109, 82-94. https://doi.org/10.1016/j.actbio.2020.03.025

The native extracellular matrix (ECM) is a complex gel-like system with a broad range of structural features and biomolecular signals. Hydrogel platforms that can recapitulate the complexity and signaling properties of this ECM would have enormous im... Read More about Multicomponent Hydrogels for the Formation of Vascularized Bone-like Constructs In Vitro.

Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices (2020)
Journal Article
Wu, Y., Okesola, B. O., Xu, J., Korotkin, I., Berado, A., Corridori, I., …Mata, A. (2020). Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices. Nature Communications, 11(1), Article 1182. https://doi.org/10.1038/s41467-020-14716-z

Supramolecular chemistry offers an exciting opportunity to assemble materials with molecular precision. However, there remains an unmet need to turn molecular self-assembly into functional materials and devices. Harnessing the inherent properties of... Read More about Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices.

Growth?Factor Free Multicomponent Nanocomposite Hydrogels That Stimulate Bone Formation (2020)
Journal Article
Okesola, B. O., Ni, S., Derkus, B., Galeano, C. C., Hasan, A., Wu, Y., …Mata, A. (2020). Growth‐Factor Free Multicomponent Nanocomposite Hydrogels That Stimulate Bone Formation. Advanced Functional Materials, 30(14), Article 1906205. https://doi.org/10.1002/adfm.201906205

Synthetic osteo?promoting materials that are able to stimulate and accelerate bone formation without the addition of exogenous cells or growth factors represent a major opportunity for an aging world population. A co?assembling system that integrates... Read More about Growth?Factor Free Multicomponent Nanocomposite Hydrogels That Stimulate Bone Formation.

Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties (2019)
Journal Article
Okesola, B. O., Lau, H. K., Derkus, B., Boccorh, D. K., Wu, Y., Wark, A. W., …Mata, A. (2020). Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties. Biomaterials Science, 8(3), 846-857. https://doi.org/10.1039/c9bm01796h

Covalent co-assembly holds great promise for the fabrication of hydrogels with controllable nanostructure, versatile chemical composition, and enhanced mechanical properties given its relative simplicity, high efficiency, and bond stability. This rep... Read More about Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties.

Protein disorder–order interplay to guide the growth of hierarchical mineralized structures (2018)
Journal Article
Elsharkawy, S., Al-Jawad, M., Pantano, M. F., Tejeda-Montes, E., Mehta, K., Jamal, H., …Mata, A. (2018). Protein disorder–order interplay to guide the growth of hierarchical mineralized structures. Nature Communications, 9, Article 2145. https://doi.org/10.1038/s41467-018-04319-0

A major goal in materials science is to develop bioinspired functional materials based on the precise control of molecular building blocks across length scales. Here we report a protein-mediated mineralization process that takes advantage of disorder... Read More about Protein disorder–order interplay to guide the growth of hierarchical mineralized structures.

Hydrodynamically Guided Hierarchical Self-Assembly of Peptide-Protein Bioinks (2018)
Journal Article
Ng, K. W., Hedegaard, C. L., Collin, E. C., Castrejón-Pita, A. A., Redondo-Gómez, C., Nguyen, L. T. H., …Mata, A. (2018). Hydrodynamically Guided Hierarchical Self-Assembly of Peptide-Protein Bioinks. Advanced Functional Materials, 28(16), Article 1703716. https://doi.org/10.1002/adfm.201703716

Effective integration of molecular self?assembly and additive manufacturing would provide a technological leap in bioprinting. This article reports on a biofabrication system based on the hydrodynamically guided co?assembly of peptide amphiphiles (PA... Read More about Hydrodynamically Guided Hierarchical Self-Assembly of Peptide-Protein Bioinks.