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Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties

Okesola, Babatunde O.; Lau, Hang K.; Derkus, Burak; Boccorh, Delali K.; Wu, Yuanhao; Wark, Alastair W.; Kiick, Kristi L.; Mata, Alvaro

Authors

Babatunde O. Okesola

Hang K. Lau

Burak Derkus

Delali K. Boccorh

Yuanhao Wu

Alastair W. Wark

Kristi L. Kiick



Abstract

Covalent co-assembly holds great promise for the fabrication of hydrogels with controllable nanostructure, versatile chemical composition, and enhanced mechanical properties given its relative simplicity, high efficiency, and bond stability. This report describes our approach to designing functional multicomponent hydrogels based on photo-induced chemical interactions between an acrylamide-functionalized resilin-like polypeptide (RLP) and a peptide amphiphile (PA). Circular dichroism (CD) spectroscopy, electron microscopy, and amplitude sweep rheology were used to demonstrate that the co-assembled hydrogel systems acquired distinct structural conformations, tunable nanostructures, and enhanced elasticity in a PA concentration-dependent manner. We envisage the use of these materials in numerous biomedical applications such as controlled drug release systems, microfluidic devices, and scaffolds for tissue engineering.

Journal Article Type Article
Publication Date Feb 7, 2020
Journal Biomaterials Science
Electronic ISSN 2047-4849
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 8
Issue 3
Pages 846-857
APA6 Citation Okesola, B. O., Lau, H. K., Derkus, B., Boccorh, D. K., Wu, Y., Wark, A. W., …Mata, A. (2020). Covalent co-assembly between resilin-like polypeptide and peptide amphiphile into hydrogels with controlled nanostructure and improved mechanical properties. Biomaterials Science, 8(3), 846-857. https://doi.org/10.1039/c9bm01796h
DOI https://doi.org/10.1039/c9bm01796h
Keywords General Materials Science; Biomedical Engineering
Publisher URL https://pubs.rsc.org/en/content/articlelanding/2019/bm/c9bm01796h/unauth#!divAbstract
Additional Information : This document is Similarity Check deposited; : Supplementary Information; : Babatunde O. Okesola (ORCID); : Babatunde O. Okesola (ResearcherID); : Burak Derkus (ORCID); : Delali K. Boccorh (ORCID); : Alastair W. Wark (ORCID); : Alastair W. Wark (ResearcherID); : Kristi L. Kiick (ORCID); : Alvaro Mata (ORCID); : Single-blind; : Received 5 November 2019; Accepted 14 November 2019; Accepted Manuscript published 19 November 2019; Advance Article published 3 December 2019
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