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Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures

Majkowska, Anna; Redondo-G�mez, Carlos; Rice, Alistair; Gonzalez, Mariel; Inostroza-Brito, Karla E; Collin, Estelle; Rodriguez-Cabello, Jose Carlos; Del Rio Hernandez, Armando E.; Solito, Egle; Mata, Alvaro

Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures Thumbnail


Authors

Anna Majkowska

Carlos Redondo-G�mez

Alistair Rice

Mariel Gonzalez

Karla E Inostroza-Brito

Estelle Collin

Jose Carlos Rodriguez-Cabello

Armando E. Del Rio Hernandez

Egle Solito



Contributors

Abstract

Multicomponent self-assembly holds great promise for the generation of complex and functional biomaterials with hierarchical microstructure. Here, we describe the use of supramolecular co-assembly between an elastin-like recombinamer (ELR5) and a peptide amphiphile (PA) to organise graphene oxide (GO) flakes into bioactive structures across multiple scales. The process takes advantage of a reaction – diffusion mechanism to enable the incorporation and spatial organization of GO within multiple ELR5/PA layers. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and ImageJ software were used to demonstrate the hierarchical organisation of GO flakes within the ELR5/PA layers and the distribution profiles of GO throughout the ELR5/PA membranes. Furthermore,atomic force microscopy (AFM) revealed improved Young’s moduli of the ELR5/PA/GOmembranes compared to the ELR5/PA membranes. Lastly, we investigated biocompatibility of the ELR5/PA/GO membrane via various cell culture methods.

Citation

Majkowska, A., Redondo-Gómez, C., Rice, A., Gonzalez, M., Inostroza-Brito, K. E., Collin, E., Rodriguez-Cabello, J. C., Del Rio Hernandez, A. E., Solito, E., & Mata, A. (2020). Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures. Frontiers in Materials, 7, Article 167. https://doi.org/10.3389/fmats.2020.00167

Journal Article Type Article
Acceptance Date May 6, 2020
Online Publication Date Jun 16, 2020
Publication Date Jun 16, 2020
Deposit Date Jun 5, 2020
Publicly Available Date Jun 16, 2020
Journal Frontiers in Materials
Electronic ISSN 2296-8016
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 7
Article Number 167
DOI https://doi.org/10.3389/fmats.2020.00167
Keywords graphene oxide, multicomponent self-assembly, peptide amphiphiles, elastin-like recombinamer, hierarchical biomaterials, composite materials
Public URL https://nottingham-repository.worktribe.com/output/4582597
Publisher URL https://www.frontiersin.org/articles/10.3389/fmats.2020.00167/full

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