Genotyping of the Alzheimer’s disease Genome-Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort

Brookes, Keeley J.; McConnell, G.; Williams, K.; Chaudhury, Sultan R; Madhan, G.; Patel, T.; Turley, C.; Guetta-Baranes, Tamar; Francis, Paul T.; Morgan, Kevin

Abstract

The Brains for Dementia Research project is a recently established cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples. Here we present the findings from our analysis on the 19 established GWAS index SNPs for Alzheimer’s disease, in order to demonstrate if the BDR sample also displays association to these variants. A highly significant association of the APOE ε4 allele was identified (P=3.99x10-12). Association tests for the 19 GWAS SNPs found that although no SNPs survive multiple testing, nominal significant findings were detected and concordance with the Lambert et al GWAS meta-analysis was observed.

Citation

Brookes, K. J., McConnell, G., Williams, K., Chaudhury, S. R., Madhan, G., Patel, T., Turley, C., Guetta-Baranes, T., Francis, P. T., & Morgan, K. (2018). Genotyping of the Alzheimer’s disease Genome-Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort. Journal of Alzheimer's Disease, 64(2), https://doi.org/10.3233/JAD-180191

• Journal Article Type: Article
• Acceptance Date: May 1, 2018
• Publication Date: Jun 19, 2018
• Deposit Date: May 2, 2018
• Publicly Available Date: Jun 19, 2018
• Journal: Journal of Alzheimer's Disease
• Print ISSN: 1387-2877
• Electronic ISSN: 1875-8908
• Publisher: IOS Press
• Peer Reviewed: Peer Reviewed
• Volume: 64
• Issue: 2
• DOI: https://doi.org/10.3233/JAD-180191
• Keywords: Alzheimer’s disease, association, Brains for Dementia Research, genome-wide association study, single nucleotide polymorphisms
• Public URL: https://nottingham-repository.worktribe.com/output/939150
• Publisher URL: https://content.iospress.com/articles/journal-of-alzheimers-disease/jad180191
• Contract Date: May 2, 2018