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Alcohol consumption and the risk of tuberculosis: a systematic review and meta-analysis

Simou, Evangelia; Britton, John; Leonardi-Bee, Jo

Alcohol consumption  and the risk of tuberculosis: a systematic review and  meta-analysis Thumbnail


Evangelia Simou

John Britton

Professor of Medical Statistics and Epidemiology


OBJECTIVE: To perform a systematic review and meta-analysis of the association between alcohol consumption and tuberculosis risk.
METHODS: Medline, EMBASE and Web of Science were searched for observational studies from 2005 to April 2018. Reference lists of included studies were screened.
RESULTS: Forty nine studies were included. Compared to people with low or no alcohol intake, the risk of tuberculosis in people with high or any alcohol consumption was increased by a relative odds of 1.90 (95% CI: 1.-2.23). Substantial levels of heterogeneity were seen (I2=82%), but there was no evidence of publication bias (P=0.). Sensitivity analysis restricted to studies using no alcohol drinking as a reference group found a slightly lower but still increased risk (Odds Ratio= 1.59, 95%CI: 1.38-1.84). Subgroup analyses found no significant differences in relation to study design and quality, geographic location, publication year, and adjustment for confounders. A pooled analysis of a further four studies reporting hazard ratios, found nearly a tripling increase in risk of TB in relation to alcohol consumption during follow-up (HR=2.81, 95%CI: 2.12-3.74). An exposure-response analysis showed that for every 10-20 grams daily alcohol intake, there was 12% increase in TB risk.
CONCLUSION: Alcohol consumption is an important risk factor for the development of TB.

Journal Article Type Article
Acceptance Date Jun 5, 2018
Online Publication Date Nov 1, 2018
Publication Date Nov 1, 2018
Deposit Date Jun 7, 2018
Publicly Available Date May 2, 2019
Journal International Journal of Tuberculosis and Lung Disease
Print ISSN 1027-3719
Electronic ISSN 1815-7920
Publisher International Union Against Tuberculosis and Lung Disease
Peer Reviewed Peer Reviewed
Volume 22
Issue 11
Pages 1277-1285
Keywords alcohol; tuberculosis; meta-analysis
Public URL
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