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Psychological interventions for mood and cognition after stroke and transient ischaemic attack: A protocol for an umbrella review

Kontou, Eirini; Shokraneh, Farhad; das Nair, Roshan; Quinn, Terry; Leonardi-Bee, Jo; Thorpe, Naomi; Clifford, Naomi; Williams, Marie; Wydera, Sandra; Drummond, Avril

Psychological interventions for mood and cognition after stroke and transient ischaemic attack: A protocol for an umbrella review Thumbnail


Farhad Shokraneh

Professor of Clinical Psychology and Neuropsychology

Terry Quinn

Professor of Evidence Synthesis

Naomi Thorpe

Naomi Clifford

Marie Williams

Sandra Wydera

Professor of Healthcare Research


Background People who have had a stroke or a Transient Ischaemic Attack (TIA) can experience psychological and/or cognitive difficulties. The body of research for psychological and neuropsychological interventions after stroke is growing, however, published systematic reviews vary in scope and methodology, with different types and severity of strokes included, and at times, diverse conclusions drawn about the effectiveness of the interventions evaluated. In this umbrella review, we aim to systematically summarise the existing systematic reviews evaluating psychological interventions for mood and cognition post-stroke/TIA. Methods We will conduct this umbrella review according to the JBI Manual for Evidence Synthesis. The following databases will be searched from inception: Cochrane Database of Systematic Reviews, Database of Reviews of Effects (DARE), MEDLINE, Embase, CINAHL, PsycINFO, and Epistemonikos. Systematic reviews with or without meta-analysis published until the search date will be included. Reviews including psychological interventions addressing mood and/or cognition outcomes for any stroke type or severity will be screened for eligibility. A narrative synthesis, including content analysis, will be used. Each stage of the review will be processed by two independent reviewers and a third reviewer will be considered to resolve disagreements. The methodological quality of the included reviews will be assessed using AMSTAR 2. Discussion Existing systematic reviews provide varied evidence on the effectiveness of psychological interventions post-stroke/TIA. This umbrella review aims to summarise knowledge and evidence on different types of psychological and neuropsychological interventions targeting mood and cognition. Findings will highlight important knowledge gaps and help prioritise future research questions. Systematic Review Registration This protocol was prospectively registered with the International Prospective Register of Systematic Reviews (PROSPERO) on November 15, 2022; PROSPERO CRD42022375947.

Journal Article Type Article
Acceptance Date Mar 20, 2024
Online Publication Date May 29, 2024
Publication Date May 29, 2024
Deposit Date Jun 10, 2024
Publicly Available Date Jun 10, 2024
Journal F1000Research
Electronic ISSN 2046-1402
Publisher F1000Research
Peer Reviewed Peer Reviewed
Volume 13
Article Number 199
Pages 1-15
Public URL
Publisher URL


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