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Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing

Lovato, Tatiana; Taresco, Vincenzo; Alazzo, Ali; Sansone, Catarina; Stolnik, Snjezana; Alexander, Cameron; Conte, Claudia

Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing Thumbnail


Authors

Tatiana Lovato

Ali Alazzo

Catarina Sansone

Snjezana Stolnik

Claudia Conte



Abstract

Here we describe a rapid inkjet formulation method for screening newly-synthesised cationic materials for siRNA delivery into cancer cells. Reduction responsive oligo-β-aminoesters were prepared and evaluated for their ability to condense siRNA into polyplexes through a fast inkjet printing method. A direct relationship between the oligomer structures and charge densities, and the final cell response in terms of uptake rate and transfection efficacy, was found. The oligo-β-aminoesters were well-tolerated by the cancer cells, compared to conventional cationic polymers so far employed in gene delivery, and were as active in silencing of a representative luciferase gene.

Citation

Lovato, T., Taresco, V., Alazzo, A., Sansone, C., Stolnik, S., Alexander, C., & Conte, C. (2018). Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing. Journal of Materials Chemistry B, 6(41), 6550-6558. https://doi.org/10.1039/C8TB01215F

Journal Article Type Article
Acceptance Date Jun 1, 2018
Online Publication Date Oct 9, 2018
Publication Date Oct 9, 2018
Deposit Date Jun 5, 2018
Publicly Available Date Oct 10, 2019
Journal Journal of Materials Chemistry B
Print ISSN 2050-750X
Electronic ISSN 2050-7518
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 6
Issue 41
Pages 6550-6558
DOI https://doi.org/10.1039/C8TB01215F
Public URL https://nottingham-repository.worktribe.com/output/935413
Publisher URL https://pubs.rsc.org/en/content/articlehtml/2018/tb/c8tb01215f
Contract Date Jun 5, 2018

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