Deepak Kakde
Amphiphilic block copolymers from a renewable Ɛ-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release
Kakde, Deepak; Taresco, Vincenzo; Bansal, Kuldeep Kumar; Magennis, E. Peter; Howdle, Steven M.; Mantovani, Giuseppe; Irvine, Derek J.; Alexander, Cameron
Authors
Dr VINCENZO TARESCO VINCENZO.TARESCO@NOTTINGHAM.AC.UK
NOTTINGHAM RESEARCH FELLOW
Kuldeep Kumar Bansal
E. Peter Magennis
Professor STEVE HOWDLE STEVE.HOWDLE@NOTTINGHAM.AC.UK
PROFESSOR OF CHEMISTRY
Dr GIUSEPPE MANTOVANI giuseppe.mantovani@nottingham.ac.uk
ASSOCIATE PROFESSOR
Professor DEREK IRVINE derek.irvine@nottingham.ac.uk
PROFESSOR OF MATERIALS CHEMISTRY
Professor CAMERON ALEXANDER CAMERON.ALEXANDER@NOTTINGHAM.AC.UK
PROFESSOR OF POLYMER THERAPEUTICS
Abstract
Here we describe a methoxy poly(ethyleneglycol)-b-poly(ε-decalactone) (mPEG-b-PεDL) copolymer and investigate the potential of the copolymer as a vehicle for solubilisation and sustained release of indomethacin (IND). The indomethacin loading and release from mPEG-b-PεDL micelles (amorphous cores) was compared against methoxy poly(ethyleneglycol)-b-poly(ε-caprolactone)(mPEG-b-PCL) micelles (semicrystalline cores). The drug–polymer compatibility was determined through a theoretical approach to predict drug incorporation into hydrated micelles. Polymer micelles were prepared by solvent evaporation and characterised for size, morphology, indomethacin loading and release. All the formulations generated spherical micelles but significantly larger mPEG-b-PεDL micelles were observed compared to mPEG-b-PCL micelles. A higher compatibility of the drug was predicted for PCL cores based on Flory–Huggins interaction parameters (χsp) using the Hansen solubility parameter (HSP) approach, but higher measured drug loadings were found in micelles with PεDL cores compared to PCL cores. This we attribute to the higher amorphous content in the PεDL-rich regions which generated higher micellar core volumes. Drug release studies showed that the semicrystalline PCL core was able to release IND over a longer period (80% drug release in 110 h) compared to PεDL core micelles (80% drug release in 72 h).
Citation
Kakde, D., Taresco, V., Bansal, K. K., Magennis, E. P., Howdle, S. M., Mantovani, G., Irvine, D. J., & Alexander, C. (in press). Amphiphilic block copolymers from a renewable Ɛ-decalactone monomer: prediction and characterization of micellar core effects on drug encapsulation and release. Journal of Materials Chemistry B, 44, https://doi.org/10.1039/C6TB01839D
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 28, 2016 |
Online Publication Date | Sep 29, 2016 |
Deposit Date | Nov 28, 2016 |
Publicly Available Date | Nov 28, 2016 |
Journal | Journal of Materials Chemistry B |
Print ISSN | 2050-750X |
Electronic ISSN | 2050-7518 |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 44 |
DOI | https://doi.org/10.1039/C6TB01839D |
Public URL | https://nottingham-repository.worktribe.com/output/808867 |
Publisher URL | http://pubs.rsc.org/en/Content/ArticleLanding/2016/TB/C6TB01839D#!divAbstract |
Contract Date | Nov 28, 2016 |
Files
Kakde et al JMC 2016 AAM.pdf
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