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Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing

Lovato, Tatiana; Taresco, Vincenzo; Alazzo, Ali; Sansone, Catarina; Stolnik, Snjezana; Alexander, Cameron; Conte, Claudia

Authors

Tatiana Lovato

Ali Alazzo

Catarina Sansone

Claudia Conte



Abstract

Here we describe a rapid inkjet formulation method for screening newly-synthesised cationic materials for siRNA delivery into cancer cells. Reduction responsive oligo-β-aminoesters were prepared and evaluated for their ability to condense siRNA into polyplexes through a fast inkjet printing method. A direct relationship between the oligomer structures and charge densities, and the final cell response in terms of uptake rate and transfection efficacy, was found. The oligo-β-aminoesters were well-tolerated by the cancer cells, compared to conventional cationic polymers so far employed in gene delivery, and were as active in silencing of a representative luciferase gene.

Journal Article Type Article
Publication Date Oct 9, 2018
Journal Journal of Materials Chemistry B
Print ISSN 2050-750X
Electronic ISSN 2050-7518
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 6
Pages 6550-6558
APA6 Citation Lovato, T., Taresco, V., Alazzo, A., Sansone, C., Stolnik, S., Alexander, C., & Conte, C. (2018). Rapid formulation of redox-responsive oligo-β-aminoester polyplexes with siRNA via jet printing. Journal of Materials Chemistry B, 6, 6550-6558. doi:10.1039/C8TB01215F
DOI https://doi.org/10.1039/C8TB01215F
Publisher URL https://pubs.rsc.org/en/content/articlehtml/2018/tb/c8tb01215f
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Accepted J Mat Chem B document unformatted.pdf (1.2 Mb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf


ESI revised for repository .pdf (2.5 Mb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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