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Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease

Sargeant, Jack A.; Bawden, Stephen; Aithal, Guruprasad P.; Simpson, Elizabeth J.; Macdonald, Ian A.; Turner, Mark C.; Cegielski, Jessica; Smith, Kenneth; Dorling, James L.; Gowland, Penny A.; Nimmo, Myra A.; King, James A.

Authors

Jack A. Sargeant

Stephen Bawden

Guruprasad P. Aithal

Elizabeth J. Simpson

Ian A. Macdonald

Mark C. Turner

Jessica Cegielski

Kenneth Smith

James L. Dorling

Penny A. Gowland

Myra A. Nimmo

James A. King



Abstract

Purpose: This study examined the feasibility of sprint interval exercise training (SIT) for men with non-alcoholic fatty liver disease (NAFLD) and its effects on intrahepatic triglyceride (IHTG), insulin sensitivity (hepatic and peripheral), visceral (VAT) and subcutaneous adipose tissue (ScAT).
Methods: Nine men with NAFLD (age 41 ± 8 years; BMI 31.7 ± 3.1 kg m−2; IHTG 15.6 ± 8.3%) were assessed at: (1) baseline (2) after a control phase of no intervention (pre-training) and (3) after 6 weeks of SIT (4–6 maximal 30 s cycling intervals, three times per week). IHTG, VAT and ScAT were measured using magnetic resonance spectroscopy or imaging and insulin sensitivity was assessed via dual-step hyperinsulinaemic-euglycaemic clamp with [6,6-D2] glucose tracer.
Results: Participants adhered to SIT, completing ≥ 96.7% of prescribed intervals. SIT increased peak oxygen uptake [ V O2peak: + 13.6% (95% CI 8.8–18.2%)] and elicited a relative reduction in IHTG [− 12.4% (− 31.6 to 6.7%)] and VAT [− 16.9% (− 24.4 to − 9.4%); n = 8], with no change in body weight or ScAT. Peripheral insulin sensitivity increased throughout the study (n = 8; significant main effect of phase) but changes from pre- to post-training were highly variable (range − 18.5 to + 58.7%) and not significant (P = 0.09), despite a moderate effect size (g* = 0.63). Hepatic insulin sensitivity was not influenced by SIT.
Conclusions: SIT is feasible for men with NAFLD in a controlled laboratory setting and is able to reduce IHTG and VAT in the absence of weight loss.

Journal Article Type Article
Publication Date Apr 30, 2018
Journal European Journal of Applied Physiology
Print ISSN 1439-6319
Electronic ISSN 1439-6319
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 118
Issue 4
APA6 Citation Sargeant, J. A., Bawden, S., Aithal, G. P., Simpson, E. J., Macdonald, I. A., Turner, M. C., …King, J. A. (2018). Effects of sprint interval training on ectopic lipids and tissue-specific insulin sensitivity in men with non-alcoholic fatty liver disease. European Journal of Applied Physiology, 118(4), https://doi.org/10.1007/s00421-018-3818-y
DOI https://doi.org/10.1007/s00421-018-3818-y
Keywords Exercise ; NAFLD ; Hepatic steatosis ; Insulin sensitivity
Publisher URL https://doi.org/10.1007/s00421-018-3818-y
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This is a post-peer-review, pre-copyedit version of an article published in European Journal of Applied Physiology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00421-018-3818-y

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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