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Advances in metabolic engineering in the microbial production of fuels and chemicals from C1 gas

Humphreys, Christopher M.; Minton, Nigel P.

Authors

NIGEL MINTON nigel.minton@nottingham.ac.uk
Professor of Appliedmolecular Microbiology



Abstract

The future sustainable production of chemicals and fuels from non-petrochemical sources, while at the same time reducing greenhouse gas (GHG) emissions, represent two of society's greatest challenges. Microbial chassis able to grow on waste carbon monoxide (CO) and carbon dioxide (CO2) can provide solutions to both. Ranging from the anaerobic acetogens, through the aerobic chemoautotrophs to the photoautotrophic cyanobacteria, they are able to convert C1 gases into a range of chemicals and fuels which may be enhanced and extended through appropriate metabolic engineering. The necessary improvements will be facilitated by the increasingly sophisticated gene tools that are beginning to emerge as part of the Synthetic Biology revolution. These tools, in combination with more accurate metabolic and genome scale models, will enable C1 chassis to deliver their full potential.

Citation

Humphreys, C. M., & Minton, N. P. (in press). Advances in metabolic engineering in the microbial production of fuels and chemicals from C1 gas. Current Opinion in Biotechnology, 50, https://doi.org/10.1016/j.copbio.2017.12.023

Journal Article Type Article
Acceptance Date Dec 22, 2017
Online Publication Date Feb 3, 2018
Deposit Date Mar 2, 2018
Publicly Available Date Mar 2, 2018
Journal Current Opinion in Biotechnology
Print ISSN 0958-1669
Electronic ISSN 1879-0429
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 50
DOI https://doi.org/10.1016/j.copbio.2017.12.023
Public URL http://eprints.nottingham.ac.uk/id/eprint/50125
Publisher URL https://doi.org/10.1016/j.copbio.2017.12.023
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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