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Patterns of grey matter loss associated with motor subscores in early Parkinson's disease

Li, Xingfeng; Xing, Yue; Martin-Bastida, Antonio; Piccini, Paola; Auer, Dorothee P.

Authors

Xingfeng Li

YUE XING Yue.Xing@nottingham.ac.uk
Research Fellow

Antonio Martin-Bastida

Paola Piccini



Abstract

Classical motor symptoms of Parkinson's disease (PD) such as tremor, rigidity, bradykinesia, and axial symptoms are graded in the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III. It is yet to be ascertained whether parkinsonian motor symptoms are associated with different anatomical patterns of neurodegeneration as reflected by brain grey matter (GM) alteration. This study aimed to investigate associations between motor subscores and brain GM at voxel level. High resolution structural MRI T1 scans from the Parkinson's Progression Markers Initiative (PPMI) repository were employed to estimate brain GM intensity of PD subjects. Correlations between GM intensity and total MDS-UPDRS III and its four subscores were computed. The total MDS-UPDRS III score was significantly negatively correlated bilaterally with putamen and caudate GM density. Lower anterior striatal GM intensity was significantly associated with higher rigidity subscores, whereas left-sided anterior striatal and precentral cortical GM reduction were correlated with severity of axial symptoms. No significant morphometric associations were demonstrated for tremor subscores. In conclusion, we provide evidence for neuroanatomical patterns underpinning motor symptoms in early PD.

Citation

Li, X., Xing, Y., Martin-Bastida, A., Piccini, P., & Auer, D. P. (in press). Patterns of grey matter loss associated with motor subscores in early Parkinson's disease. NeuroImage: Clinical, 17, https://doi.org/10.1016/j.nicl.2017.11.009

Journal Article Type Article
Acceptance Date Nov 8, 2017
Online Publication Date Nov 10, 2017
Deposit Date Nov 24, 2017
Publicly Available Date Nov 24, 2017
Journal NeuroImage: Clinical
Electronic ISSN 2213-1582
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 17
DOI https://doi.org/10.1016/j.nicl.2017.11.009
Keywords Parkinson's disease; MDS-UPDRS III; Motor symptoms; MRI grey matter; PD subtypes
Public URL http://eprints.nottingham.ac.uk/id/eprint/48360
Publisher URL https://doi.org/10.1016/j.nicl.2017.11.009
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0







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