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How have retrovirus pseudotypes contributed to our understanding of viral entry?

Tarr, Alexander W.; King, Barnabas


Barnabas King


Study of virus entry into host cells is important for understanding viral tropism and pathogenesis. Studying the entry of in vitro cultured viruses is not always practicable. Study of highly pathogenic viruses, viruses that do not grow in culture, and viruses that rapidly change phenotype in vitro can all benefit from alternative models of entry. Retrovirus particles can be engineered to display the envelope proteins of heterologous enveloped viruses. This approach, broadly termed ‘pseudotyping’, is an important technique for interrogating virus entry. In this perspective we consider how retrovirus pseudotypes have addressed these challenges and improved our understanding of the entry pathways of diverse virus species, including Ebolavirus, human immunodeficiency virus and hepatitis C virus.


Tarr, A. W., & King, B. (2017). How have retrovirus pseudotypes contributed to our understanding of viral entry?. Future Virology, 12(10), Article 0062.

Journal Article Type Article
Acceptance Date Jul 17, 2017
Online Publication Date Sep 29, 2017
Publication Date Oct 31, 2017
Deposit Date Oct 3, 2017
Publicly Available Date Sep 30, 2018
Journal Future Virology
Print ISSN 1746-0794
Electronic ISSN 1746-0808
Publisher Future Medicine
Peer Reviewed Peer Reviewed
Volume 12
Issue 10
Article Number 0062
Keywords Pseudotype, Pseudoparticle, Entry pathway
Public URL
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