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From start to finish: amino-terminal protein modifications as degradation signals in plants

Gibbs, Daniel J.; Bailey, Mark; Tedds, Hannah M.; Holdsworth, Michael J.

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Authors

Daniel J. Gibbs

Mark Bailey

Hannah M. Tedds



Abstract

The amino- (N-) terminus (Nt) of a protein can undergo a diverse array of co- and posttranslational modifications. Many of these create degradation signals (N-degrons) that mediate protein destruction via the N-end rule pathway of ubiquitin-mediated proteolysis. In plants, the N-end rule pathway has emerged as a major system for regulated control of protein stability. Nt-arginylation-dependent degradation regulates multiple growth, development and stress responses, and recently identified functions of Nt-acetylation can also be linked to effects on the in vivo half-lives of Nt-acetylated proteins. There is also increasing evidence that N-termini could act as important protein stability determinants in plastids. Here we review recent advances in our understanding of the relationship between the nature of protein N-termini, Nt-processing events and proteolysis in plants.

Citation

Gibbs, D. J., Bailey, M., Tedds, H. M., & Holdsworth, M. J. (2016). From start to finish: amino-terminal protein modifications as degradation signals in plants. New Phytologist, 211(4), 1188-1194. https://doi.org/10.1111/nph.14105

Journal Article Type Article
Acceptance Date Jun 7, 2016
Online Publication Date Jul 21, 2016
Publication Date Sep 1, 2016
Deposit Date Nov 25, 2016
Publicly Available Date Nov 25, 2016
Journal New Phytologist
Print ISSN 0028-646X
Electronic ISSN 1469-8137
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 211
Issue 4
Pages 1188-1194
DOI https://doi.org/10.1111/nph.14105
Keywords N-terminus, proteolysis, N-end rule, N-degron, protein modification, Nt-12 acetylation, protease, ubiquitin proteasome system
Public URL https://nottingham-repository.worktribe.com/output/800005
Publisher URL http://onlinelibrary.wiley.com/doi/10.1111/nph.14105/full
Additional Information This is the peer reviewed version of the following article: Gibbs, D. J., Bailey, M., Tedds, H. M. and Holdsworth, M. J. (2016), From start to finish: amino-terminal protein modifications as degradation signals in plants. New Phytologist, 211: 1188–1194., which has been published in final form at http://dx.doi.org/10.1111/nph.14105. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Contract Date Nov 25, 2016

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