Incidence of ANCA-associated vasculitis in a UK mixed ethnicity population

Pearce, Fiona A; Lanyon, Peter C.; Grainge, Matthew J.; Shaunak, Reena; Mahr, Alfred; Hubbard, Richard B.; Watts, Richard A

Abstract

Objectives: We aimed to estimate the incidence of ANCA-associated vasculitis in the UK and how this varied by ethnic group.
Methods: We identified incident cases of ANCA-associated vasculitis between March 2007 and June 2013 in the Nottingham–Derby urban area from medical records using multiple sources. We derived the denominator population from the 2011 census, and we calculated incidence rate ratios using Poisson regression.
Results: Overall, we identified 107 cases of ANCA-associated vasculitis, giving an incidence of 23.1 per million person-years (95% CI: 18.9, 27.9). The incidence among the white population was 25.8 per million person-years (95% CI: 21.0, 31.3) and among the black and minority ethnic (BME) population 8.4 per million person-years (95% CI: 3.1, 18.3). After adjustment for age and sex, the difference between ethnic groups was not statistically significant (incidence rate ratio 0.7, 95% CI: 0.3, 1.5, P = 0.3).
Conclusion: Overall, the incidence of ANCA-associated vasculitis was similar to other epidemiological studies. Crude incidence rates were lower in the BME than in the white population, but this was partly explained by the older age profile among the white compared with BME population.

Citation

Pearce, F. A., Lanyon, P. C., Grainge, M. J., Shaunak, R., Mahr, A., Hubbard, R. B., & Watts, R. A. (in press). Incidence of ANCA-associated vasculitis in a UK mixed ethnicity population. Rheumatology, 55(9), https://doi.org/10.1093/rheumatology/kew232

• Journal Article Type: Article
• Acceptance Date: Apr 22, 2016
• Online Publication Date: Jun 5, 2016
• Deposit Date: Jun 15, 2016
• Publicly Available Date: Jun 15, 2016
• Journal: Rheumatology
• Electronic ISSN: 1462-0324
• Publisher: Oxford University Press
• Peer Reviewed: Peer Reviewed
• Volume: 55
• Issue: 9
• DOI: https://doi.org/10.1093/rheumatology/kew232
• Keywords: Incidence, Epidemiology, Vasculitis; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, ; Granulomatosis with Polyangiitis,; Microscopic Polyangiitis,Eosinophilic granulomatosis with polyangiitis, Ethnic Groups
• Public URL: https://nottingham-repository.worktribe.com/output/796553
• Publisher URL: http://rheumatology.oxfordjournals.org/content/early/2016/06/03/rheumatology.kew232.abstract
• Additional Information: This is a pre-copyedited, author-produced PDF of an article accepted for publication in Rheumatology following peer review. The version of record Incidence of ANCA-associated vasculitis in a UK mixed ethnicity population / Fiona A. Pearce, Peter C. Lanyon, Matthew J. Grainge, Reena Shaunak, Alfred Mahr, Richard B. Hubbard and Richard A. Watt. Rheumatology, (2016) 55 (9): 1656-1663 is available online at: http://rheumatology.oxfordjournals.org/content/55/9/1656
• Contract Date: Jun 15, 2016