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Incidence of ANCA-associated vasculitis in a UK mixed ethnicity population

Pearce, Fiona A; Lanyon, Peter C.; Grainge, Matthew J.; Shaunak, Reena; Mahr, Alfred; Hubbard, Richard B.; Watts, Richard A


Clinical Associate Professor

Peter C. Lanyon

Reena Shaunak

Alfred Mahr

Blf/Gsk Professor of Epidemiological Resp Research

Richard A Watts


Objectives: We aimed to estimate the incidence of ANCA-associated vasculitis in the UK and how this varied by ethnic group.
Methods: We identified incident cases of ANCA-associated vasculitis between March 2007 and June 2013 in the Nottingham–Derby urban area from medical records using multiple sources. We derived the denominator population from the 2011 census, and we calculated incidence rate ratios using Poisson regression.
Results: Overall, we identified 107 cases of ANCA-associated vasculitis, giving an incidence of 23.1 per million person-years (95% CI: 18.9, 27.9). The incidence among the white population was 25.8 per million person-years (95% CI: 21.0, 31.3) and among the black and minority ethnic (BME) population 8.4 per million person-years (95% CI: 3.1, 18.3). After adjustment for age and sex, the difference between ethnic groups was not statistically significant (incidence rate ratio 0.7, 95% CI: 0.3, 1.5, P = 0.3).
Conclusion: Overall, the incidence of ANCA-associated vasculitis was similar to other epidemiological studies. Crude incidence rates were lower in the BME than in the white population, but this was partly explained by the older age profile among the white compared with BME population.


Pearce, F. A., Lanyon, P. C., Grainge, M. J., Shaunak, R., Mahr, A., Hubbard, R. B., & Watts, R. A. (in press). Incidence of ANCA-associated vasculitis in a UK mixed ethnicity population. Rheumatology, 55(9),

Journal Article Type Article
Acceptance Date Apr 22, 2016
Online Publication Date Jun 5, 2016
Deposit Date Jun 15, 2016
Publicly Available Date Jun 15, 2016
Journal Rheumatology
Electronic ISSN 1462-0332
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 55
Issue 9
Keywords Incidence, Epidemiology, Vasculitis
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis,
Granulomatosis with Polyangiitis,
Microscopic Polyangiitis,Eosinophilic granulomatosis with polyangiitis, Ethnic Groups
Public URL
Publisher URL
Additional Information This is a pre-copyedited, author-produced PDF of an article accepted for publication in Rheumatology following peer review. The version of record Incidence of ANCA-associated vasculitis in a UK mixed ethnicity population / Fiona A. Pearce, Peter C. Lanyon, Matthew J. Grainge, Reena Shaunak, Alfred Mahr, Richard B. Hubbard and Richard A. Watt. Rheumatology, (2016) 55 (9): 1656-1663 is available online at:


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