NAAVENTHAN PALANIYAPPAN Naaventhan.Palaniyappan@nottingham.ac.uk
Clinical Associate Professor in Hepatology
Long-term outcomes (beyond 5 years) of liver transplant recipients--a transatlantic multicenter study
Palaniyappan, Naaventhan; Peach, Emily; Pearce, Fiona; Dhaliwal, Amritpal; Campos-Varela, Isabel; Cant, Matthew R; Dopazo, Cristina; Trotter, James; Divani-Patel, Sapna; Hatta, Ayiesha AZ; Hopkins, Laurence; Testa, Giuliano; Bilbao, Angela; Kasmani, Zain; Faloon, Sarah; Mirza, Darius F; Klintmalm, Goran B; Bilbao, Itxarone; Asrani, Sumeet K; Rajoriya, Neil; Aravinthan, Aloysious D
Authors
Emily Peach
FIONA PEARCE Fiona.Pearce@nottingham.ac.uk
Clinical Associate Professor
Amritpal Dhaliwal
Isabel Campos-Varela
Matthew R Cant
Cristina Dopazo
James Trotter
Sapna Divani-Patel
Ayiesha AZ Hatta
Laurence Hopkins
Giuliano Testa
Angela Bilbao
Zain Kasmani
Sarah Faloon
Darius F Mirza
Goran B Klintmalm
Itxarone Bilbao
Sumeet K Asrani
Neil Rajoriya
ALOYSIOUS ARAVINTHAN ALOYSIOUS.ARAVINTHAN@NOTTINGHAM.AC.UK
Clinical Associate Professor
Abstract
The long-term (>5y) outcomes following liver transplantation (LT) have not been extensively reported. The aim was to evaluate outcomes of LT recipients who have survived the first 5 years. A multicenter retrospective analysis of prospectively collected data from 3 high volume LT centers (Dallas-USA, Birmingham-UK, and Barcelona-Spain) was undertaken. All adult patients, who underwent LT since the inception of the program to December 31, 2010, and survived at least 5 years since their LT were included. Patient survival was the primary outcome. A total of 3682 patients who survived at least 5 years following LT (long-term survivors) were included. Overall, median age at LT was 52 years (IQR 44-58); 53.1% were males; and 84.6% were Caucasians. A total of 49.4% (n=1820) died during a follow-up period of 36,828 person-years (mean follow-up 10y). A total of 80.2% (n=1460) of all deaths were premature deaths. Age-standardized all-cause mortality as compared to general population was 3 times higher for males and 5 times higher for females. On adjusted analysis, besides older recipients and older donors, predictors of long-term mortality were malignancy, cardiovascular disease, and dialysis. Implementation of strategies such as noninvasive cancer screening, minimizing immunosuppression, and intensive primary/secondary cardiovascular prevention could further improve survival.
Citation
Palaniyappan, N., Peach, E., Pearce, F., Dhaliwal, A., Campos-Varela, I., Cant, M. R., …Aravinthan, A. D. (2024). Long-term outcomes (beyond 5 years) of liver transplant recipients--a transatlantic multicenter study. Liver Transplantation, 30(2), 170-181. https://doi.org/10.1097/LVT.0000000000000244
Journal Article Type | Article |
---|---|
Acceptance Date | Jul 9, 2023 |
Online Publication Date | Aug 18, 2023 |
Publication Date | Feb 1, 2024 |
Deposit Date | Jul 25, 2023 |
Publicly Available Date | Aug 19, 2024 |
Journal | Liver Transplantation |
Print ISSN | 1527-6465 |
Electronic ISSN | 1527-6473 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 30 |
Issue | 2 |
Pages | 170-181 |
DOI | https://doi.org/10.1097/LVT.0000000000000244 |
Keywords | Transplantation; Hepatology; Surgery |
Public URL | https://nottingham-repository.worktribe.com/output/23476905 |
Publisher URL | https://journals.lww.com/lt/abstract/9900/long_term_outcomes__beyond_5_years__of_liver.232.aspx |
Additional Information | This is the peer reviewed version of the following article: Palaniyappan, Naaventhan1,2; Peach, Emily3; Pearce, Fiona1,3; Dhaliwal, Amritpal4; Campos-Varela, Isabel5,6; Cant, Matthew R.4; Dopazo, Cristina7; Trotter, James8; Divani-Patel, Sapna4; Hatta, Ayiesha AZ4; Hopkins, Laurence4; Testa, Giuliano8; Bilbao, Angela7; Kasmani, Zain4; Faloon, Sarah4; Mirza, Darius F4,9; Klintmalm, Goran B8; Bilbao, Itxarone7; Asrani, Sumeet K8; Rajoriya, Neil4,10; Aravinthan, Aloysious D1,2. Long-term outcomes (beyond 5 years) of liver transplant recipients - a transatlantic multicentre study. Liver Transplantation ():10.1097/LVT.0000000000000244, August 18, 2023. , which has been published in final form at 10.1097/LVT.0000000000000244 |
Files
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