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Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation

Smith, James G. W.; Celiz, Adam D.; Smith, James G.W.; Patel, Asha K.; Hook, Andrew L.; Rajamohan, Divya; George, Vinoj T.; Flatt, Luke; Patel, Minal J.; Epa, Vidana C.; Singh, Taranjit; Langer, Robert; Anderson, Daniel G.; Allen, Nicholas D.; Hay, David C.; Winkler, David A.; Barrett, David A.; Davies, Martyn C.; Young, Lorraine E.; Denning, Chris; Alexander, Morgan R.

Authors

James G. W. Smith

Adam D. Celiz

James G.W. Smith

Asha K. Patel

ANDREW HOOK ANDREW.HOOK@NOTTINGHAM.AC.UK
Nottingham Research Fellow

Divya Rajamohan

Vinoj T. George

Luke Flatt

Minal J. Patel

Vidana C. Epa

Taranjit Singh

Robert Langer

Daniel G. Anderson

Nicholas D. Allen

David C. Hay

David A. Winkler

David A. Barrett

Martyn C. Davies

Lorraine E. Young

CHRIS DENNING chris.denning@nottingham.ac.uk
Professor of Stem Cell Biology



Abstract

A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.

Journal Article Type Article
Publication Date 2015-07
Journal Advanced Materials
Print ISSN 0935-9648
Electronic ISSN 0935-9648
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 27
Issue 27
Pages 4006-4012
APA6 Citation Smith, J. G. W., Celiz, A. D., Smith, J. G., Patel, A. K., Hook, A. L., Rajamohan, D., …Alexander, M. R. (2015). Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation. Advanced Materials, 27(27), 4006-4012. https://doi.org/10.1002/adma.201501351
DOI https://doi.org/10.1002/adma.201501351
Keywords high throughput; human pluripotent stem cells; materials discovery; polymer microarrays; stem cell differentiation
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/adma.201501351/full
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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