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Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation

Smith, James G. W.; Celiz, Adam D.; Smith, James G.W.; Patel, Asha K.; Hook, Andrew L.; Rajamohan, Divya; George, Vinoj T.; Flatt, Luke; Patel, Minal J.; Epa, Vidana C.; Singh, Taranjit; Langer, Robert; Anderson, Daniel G.; Allen, Nicholas D.; Hay, David C.; Winkler, David A.; Barrett, David A.; Davies, Martyn C.; Young, Lorraine E.; Denning, Chris; Alexander, Morgan R.


James G. W. Smith

Adam D. Celiz

James G.W. Smith

Asha K. Patel

Divya Rajamohan

Vinoj T. George

Luke Flatt

Minal J. Patel

Vidana C. Epa

Taranjit Singh

Robert Langer

Daniel G. Anderson

Nicholas D. Allen

David C. Hay

David A. Winkler

David A. Barrett

Martyn C. Davies

Lorraine E. Young

Professor of Stem Cell Biology


© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.


Smith, J. G. W., Celiz, A. D., Smith, J. G., Patel, A. K., Hook, A. L., Rajamohan, D., …Alexander, M. R. (2015). Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation. Advanced Materials, 27(27), 4006-4012.

Journal Article Type Article
Acceptance Date Apr 23, 2015
Online Publication Date Jun 1, 2015
Publication Date Jul 15, 2015
Deposit Date Dec 7, 2017
Publicly Available Date Dec 7, 2017
Journal Advanced Materials
Print ISSN 0935-9648
Electronic ISSN 1521-4095
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 27
Issue 27
Pages 4006-4012
Keywords high throughput; human pluripotent stem cells; materials discovery; polymer microarrays; stem cell differentiation
Public URL
Publisher URL


Celiz_et_al-2015-Advanced_Materials.pdf (1.6 Mb)

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