Fabiana Zingone
Incidence and distribution of coeliac disease in Campania (Italy): 2011–2013
Zingone, Fabiana; West, Joe; Auricchio, Renata; Maria Bevilacqua, Rosa; Bile, Guido; Borgheresi, Patrizia; Erminia Bottiglieri, Maria; Caldore, Mariano; Capece, Giuseppe; Cristina Caria, Maria; Crudele, Antonio; Cuomo, Rosario; Lucia Garofano, Maria; Giardullo, Nicola; Gerarda Gravina, Antonietta; Greco, Luigi; Iannotta, Patrizia; Kosova, Paolo; Lamanda, Roberto; Malamisura, Basilio; Marmo, Riccardo; Napoli, Gianfranco; Nardone, Gerardo; Pacelli, Maria; Pascarella, Filomena; Riccio, Elisabetta; Riegler, Gabriele; Rispo, Antonio; Rocco, Alba; Romano, Marco; Saffiotti, Ottavio; Saviano, Paola; Sorrentini, Italo; Speranza,, Pietro; Tolone, Carlo; Tortora, Raffaella; Troncone, Riccardo; Ciacci, Carolina
Authors
Professor JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
PROFESSOR OF EPIDEMIOLOGY
Renata Auricchio
Rosa Maria Bevilacqua
Guido Bile
Patrizia Borgheresi
Maria Erminia Bottiglieri
Mariano Caldore
Giuseppe Capece
Maria Cristina Caria
Antonio Crudele
Rosario Cuomo
Maria Lucia Garofano
Nicola Giardullo
Antonietta Gerarda Gravina
Luigi Greco
Patrizia Iannotta
Paolo Kosova
Roberto Lamanda
Basilio Malamisura
Riccardo Marmo
Gianfranco Napoli
Gerardo Nardone
Maria Pacelli
Filomena Pascarella
Elisabetta Riccio
Gabriele Riegler
Antonio Rispo
Alba Rocco
Marco Romano
Ottavio Saffiotti
Paola Saviano
Italo Sorrentini
Pietro Speranza,
Carlo Tolone
Raffaella Tortora
Riccardo Troncone
Carolina Ciacci
Abstract
BACKGROUND: There exists a wide variation in the reported incidence of coeliac disease in recent decades. We aimed to evaluate the incidence rate of coeliac diagnoses performed in an Italian region, Campania, between 2011 and 2013 and its variation therein.
METHODS: All coeliac diagnoses made from 2011 to 2013 and registered within the Campania coeliac disease register (CeliacDB) were identified. Incidence rates were analysed by sex, age and province of residence, with a Poisson model fitted to determine incidence rate ratios.
RESULTS: We found 2049 coeliac disease diagnoses registered in the CeliacDB between 2011 and 2013; 1441 of these patients were female (70.4%) and 1059 were aged less than 19 years (51.7%). The overall incidence of coeliac disease in Campania was 11.8 per 100,000 person-years (95% CI 11.3–12.3) during the study period, with marked variation by age [27.4 per 100,000 person-years (95% CI 25.8–29.1) in children under 19 years of age and 7.3 per 100,000 (95% CI 6.8–7.8) in adults] and sex [16.1 per 100,000 person-years in females (95% CI 15.3–16.9) and 7.2 per 100,000 person-years in males (95% CI 6.6–7.8)]. Coeliac disease incidence was roughly similar in Naples, Salerno, Caserta and Avellino, but about half in Benevento. More than 80% of our study population was diagnosed by the combination of positive antitransglutaminase IgA and Marsh 3. More than half of the patients were symptomatic at the time of coeliac disease diagnosis (39.7% had a classical presentation and 21.1% a non-classical one according to the Oslo definition).
CONCLUSIONS: Coeliac disease incidence was roughly similar among Campania provinces, except in Benevento where it was about half, probably due to less awareness of coeliac disease in this area. The incidence of coeliac disease in Campania appears to be lower than that reported by most of the previous literature, suggesting the necessity of new coeliac awareness programmes.
Citation
Zingone, F., West, J., Auricchio, R., Maria Bevilacqua, R., Bile, G., Borgheresi, P., Erminia Bottiglieri, M., Caldore, M., Capece, G., Cristina Caria, M., Crudele, A., Cuomo, R., Lucia Garofano, M., Giardullo, N., Gerarda Gravina, A., Greco, L., Iannotta, P., Kosova, P., Lamanda, R., Malamisura, B., …Ciacci, C. (2015). Incidence and distribution of coeliac disease in Campania (Italy): 2011–2013. United European Gastroenterology Journal, 3(2), https://doi.org/10.1177/2050640615571021
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 17, 2014 |
Online Publication Date | Feb 11, 2015 |
Publication Date | Apr 1, 2015 |
Deposit Date | Apr 20, 2016 |
Publicly Available Date | Apr 20, 2016 |
Journal | United European Gastroenterology Journal |
Print ISSN | 2050-6406 |
Electronic ISSN | 2050-6414 |
Publisher | SAGE Publications |
Peer Reviewed | Peer Reviewed |
Volume | 3 |
Issue | 2 |
DOI | https://doi.org/10.1177/2050640615571021 |
Keywords | Coeliac disease, Incidence, Clinical presentation, Italy |
Public URL | https://nottingham-repository.worktribe.com/output/746169 |
Publisher URL | http://ueg.sagepub.com/content/3/2/182 |
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