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Psychological morbidity of celiac disease: a review of the literature

Zingone, Fabiana; Swift, Gillian L; Card, Timothy R.; Sanders, David S; Ludvigsson, Jonas F.; Bai, Julio C.


Fabiana Zingone

Gillian L Swift

Clinical Associate Professor

David S Sanders

Jonas F. Ludvigsson

Julio C. Bai


BACKGROUND: Celiac disease has been linked to decreased quality of life and certain mood disorders. The effect of the gluten free diet on these psychological aspects of the disease is still unclear.

OBJECTIVES: The objective of this article is to review the literature on psychological morbidity of celiac disease.

METHODS: We performed a PubMed search for the time period from 1900 until June 1, 2014, to identify papers on psychological aspects of celiac disease looking specifically at quality of life, anxiety, depression and fatigue.

RESULTS: Anxiety, depression and fatigue are common complaints in patients with untreated celiac disease and contribute to lower quality of life. While aspects of these conditions may improve within a few months after starting a gluten-free diet, some patients continue to suffer from significant psychological morbidity. Psychological symptoms may affect the quality of life and the dietary adherence.

CONCLUSION: Health care professionals need to be aware of the ongoing psychological burden of celiac disease in order to support patients with this disease.


Zingone, F., Swift, G. L., Card, T. R., Sanders, D. S., Ludvigsson, J. F., & Bai, J. C. (2015). Psychological morbidity of celiac disease: a review of the literature. United European Gastroenterology Journal, 3(2),

Journal Article Type Article
Acceptance Date Oct 29, 2014
Online Publication Date Nov 28, 2014
Publication Date Apr 1, 2015
Deposit Date Aug 15, 2016
Publicly Available Date Aug 15, 2016
Journal United European Gastroenterology Journal
Print ISSN 2050-6406
Electronic ISSN 2050-6414
Publisher SAGE Publications
Peer Reviewed Peer Reviewed
Volume 3
Issue 2
Keywords anxiety, depression, fatigue, gluten, quality of life
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