I Amelio
miR-24 affects hair follicle morphogenesis targeting Tcf-3
Amelio, I; Lena, A M; Bonanno, E; Melino, G; Candi, E
Authors
A M Lena
E Bonanno
G Melino
E Candi
Abstract
During embryonic development, hair follicles (HFs) develop from an epidermal–mesenchymal cross talk between the ectoderm progenitor layer and the underlying dermis. Epidermal stem cell activation represents a crucial point both for HF morphogenesis and for hair regeneration. miR-24 is an anti-proliferative microRNA (miRNA), which is induced during differentiation of several cellular systems including the epidermis. Here, we show that miR-24 is expressed in the HF and has a role in hair morphogenesis. We generated transgenic mice ectopically expressing miR-24 under the K5 promoter. The K5::miR-24 animals display a marked defect in HF morphogenesis, with thinning of hair coat and altered HF structure. Expression of miR-24 alters the normal process of hair keratinocyte differentiation, leading to altered expression of differentiation markers. MiR-24 directly represses the hair keratinocyte stemness regulator Tcf-3. These results support the notion that microRNAs, and among them miR-24, have an important role in postnatal epidermal homeostasis.
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 30, 2013 |
Online Publication Date | Nov 14, 2013 |
Publication Date | 2013-11 |
Deposit Date | Apr 1, 2020 |
Journal | Cell Death & Disease |
Print ISSN | 2041-4889 |
Publisher | Springer Nature [academic journals on nature.com] |
Peer Reviewed | Peer Reviewed |
Volume | 4 |
Issue | 11 |
Article Number | e922 |
DOI | https://doi.org/10.1038/cddis.2013.426 |
Public URL | https://nottingham-repository.worktribe.com/output/4237224 |
Publisher URL | https://www.nature.com/articles/cddis2013426 |
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