Skip to main content

Research Repository

Advanced Search

Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration

Vallieres, Cindy; Hook, Andrew L.; He, Yinfeng; Crucitti, Valentina Cuzzucoli; Figueredo, Grazziela; Davies, Catheryn R.; Burroughs, Laurence; Winkler, David A.; Wildman, Ricky D.; Irvine, Derek J.; Alexander, Morgan R.; Avery, Simon V.


Cindy Vallieres

Transitional Assistant Professor

Valentina Cuzzucoli Crucitti

Catheryn R. Davies

Laurence Burroughs

David A. Winkler

Professor of Multiphase Flow and Mechanics

Professor of Materials Chemistry

Professor of Eukaryotic Microbiology


© 2020 The Authors. Fungi have major, negative socioeconomic impacts, but control with bioactive agents is increasingly restricted, while resistance is growing. Here, we describe an alternative fungal control strategy via materials operating passively (i.e., no killing effect). We screened hundreds of (meth)acrylate polymers in high throughput, identifying several that reduce attachment of the human pathogen Candida albicans, the crop pathogen Botrytis cinerea, and other fungi. Specific polymer functional groups were associated with weak attachment. Low fungal colonization materials were not toxic, supporting their passive, anti-attachment utility. We developed a candidate monomer formulation for inkjet-based 3D printing. Printed voice prosthesis components showed up to 100% reduction in C. albicans biofilm versus commercial materials. Furthermore, spray-coated leaf surfaces resisted fungal infection, with no plant toxicity. This is the first high-throughput study of polymer chemistries resisting fungal attachment. These materials are ready for incorporation in products to counteract fungal deterioration of goods, food security, and health.


Vallieres, C., Hook, A. L., He, Y., Crucitti, V. C., Figueredo, G., Davies, C. R., …Avery, S. V. (2020). Discovery of (meth)acrylate polymers that resist colonization by fungi associated with pathogenesis and biodeterioration. Science Advances, 6(23), Article eaba6574.

Journal Article Type Article
Acceptance Date Mar 21, 2020
Online Publication Date Jun 5, 2020
Publication Date Jun 1, 2020
Deposit Date Mar 26, 2020
Publicly Available Date Mar 26, 2020
Journal Science Advances
Electronic ISSN 2375-2548
Publisher American Association for the Advancement of Science
Peer Reviewed Peer Reviewed
Volume 6
Issue 23
Article Number eaba6574
Public URL
Publisher URL


You might also like

Downloadable Citations