Dr SALLY WHEATLEY sally.wheatley@nottingham.ac.uk
ASSISTANT PROFESSOR
Survivin at a glance
Wheatley, Sally P.; Altieri, Dario C.
Authors
Dario C. Altieri
Abstract
Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target. In this Cell Science at a Glance article and accompanying poster, we summarise our knowledge of survivin 21 years on from its initial discovery. We describe the structure, expression and function of survivin, highlight its interactome and conclude by describing anti-survivin strategies being trialled.
Citation
Wheatley, S. P., & Altieri, D. C. (2019). Survivin at a glance. Journal of Cell Science, 132(7), Article jcs223826. https://doi.org/10.1242/jcs.223826
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 28, 2019 |
Online Publication Date | Apr 4, 2019 |
Publication Date | Apr 1, 2019 |
Deposit Date | Apr 27, 2020 |
Publicly Available Date | Apr 27, 2020 |
Journal | Journal of Cell Science |
Print ISSN | 0021-9533 |
Electronic ISSN | 1477-9137 |
Publisher | Company of Biologists |
Peer Reviewed | Peer Reviewed |
Volume | 132 |
Issue | 7 |
Article Number | jcs223826 |
DOI | https://doi.org/10.1242/jcs.223826 |
Keywords | Cell Biology |
Public URL | https://nottingham-repository.worktribe.com/output/3017639 |
Publisher URL | https://jcs.biologists.org/content/132/7/jcs223826 |
Files
jcs223826.full
(931 Kb)
PDF
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