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Survivin at a glance

Wheatley, Sally P.; Altieri, Dario C.

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Authors

Dario C. Altieri



Abstract

Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target. In this Cell Science at a Glance article and accompanying poster, we summarise our knowledge of survivin 21 years on from its initial discovery. We describe the structure, expression and function of survivin, highlight its interactome and conclude by describing anti-survivin strategies being trialled.

Citation

Wheatley, S. P., & Altieri, D. C. (2019). Survivin at a glance. Journal of Cell Science, 132(7), Article jcs223826. https://doi.org/10.1242/jcs.223826

Journal Article Type Article
Acceptance Date Feb 28, 2019
Online Publication Date Apr 4, 2019
Publication Date Apr 1, 2019
Deposit Date Apr 27, 2020
Publicly Available Date Apr 27, 2020
Journal Journal of Cell Science
Print ISSN 0021-9533
Electronic ISSN 1477-9137
Publisher Company of Biologists
Peer Reviewed Peer Reviewed
Volume 132
Issue 7
Article Number jcs223826
DOI https://doi.org/10.1242/jcs.223826
Keywords Cell Biology
Public URL https://nottingham-repository.worktribe.com/output/3017639
Publisher URL https://jcs.biologists.org/content/132/7/jcs223826

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