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Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation


Olutoba Sanni

Professor of Materials Chemistry

Professor of Molecular Microbiology


ynthetic materials are an everyday component of modern healthcare yet often fail routinely as a consequence of medical‐device‐centered infections. The incidence rate for catheter‐associated urinary tract infections is between 3% and 7% for each day of use, which means that infection is inevitable when resident for sufficient time. The O'Neill Review on antimicrobial resistance estimates that, left unchecked, ten million people will die annually from drug‐resistant infections by 2050. Development of biomaterials resistant to bacterial colonization can play an important role in reducing device‐associated infections. However, rational design of new biomaterials is hindered by the lack of quantitative structure–activity relationships (QSARs). Here, the development of a predictive QSAR is reported for bacterial biofilm formation on a range of polymers, using calculated molecular descriptors of monomer units to discover and exemplify novel, biofilm‐resistant (meth‐)acrylate‐based polymers. These predictions are validated successfully by the synthesis of new monomers which are polymerized to create coatings found to be resistant to biofilm formation by six different bacterial pathogens: Pseudomonas aeruginosa, Proteus mirabilis, Enterococcus faecalis, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus.


Dundas, A. A., Sanni, O., Dubern, J., Dimitrakis, G., Hook, A. L., Irvine, D. J., …Alexander, M. R. (2019). Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation. Advanced Materials, 31(49), Article 1903513.

Journal Article Type Article
Acceptance Date Sep 3, 2019
Online Publication Date Oct 3, 2019
Publication Date Dec 6, 2019
Deposit Date Sep 13, 2019
Publicly Available Date Oct 9, 2019
Journal Advanced Materials
Print ISSN 0935-9648
Electronic ISSN 1521-4095
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 31
Issue 49
Article Number 1903513
Keywords low-fouling; polymer microarray; QSAR; transesterification; biofilms
Public URL
Publisher URL
Additional Information Received: 2019-06-03; Published: 2019-10-03


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