ADAM DUNDAS Adam.Dundas1@nottingham.ac.uk
Research Fellow
Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation
Authors
Olutoba Sanni
JEAN DUBERN jean.dubern@nottingham.ac.uk
Research Fellow
GEORGIOS DIMITRAKIS GEORGIOS.DIMITRAKIS@NOTTINGHAM.AC.UK
Associate Professor
ANDREW HOOK ANDREW.HOOK@NOTTINGHAM.AC.UK
Assistant Professor
DEREK IRVINE derek.irvine@nottingham.ac.uk
Professor of Materials Chemistry
PAUL WILLIAMS paul.williams@nottingham.ac.uk
Professor of Molecular Microbiology
MORGAN ALEXANDER morgan.alexander@nottingham.ac.uk
Professor of Biomedical Surfaces
Abstract
ynthetic materials are an everyday component of modern healthcare yet often fail routinely as a consequence of medical‐device‐centered infections. The incidence rate for catheter‐associated urinary tract infections is between 3% and 7% for each day of use, which means that infection is inevitable when resident for sufficient time. The O'Neill Review on antimicrobial resistance estimates that, left unchecked, ten million people will die annually from drug‐resistant infections by 2050. Development of biomaterials resistant to bacterial colonization can play an important role in reducing device‐associated infections. However, rational design of new biomaterials is hindered by the lack of quantitative structure–activity relationships (QSARs). Here, the development of a predictive QSAR is reported for bacterial biofilm formation on a range of polymers, using calculated molecular descriptors of monomer units to discover and exemplify novel, biofilm‐resistant (meth‐)acrylate‐based polymers. These predictions are validated successfully by the synthesis of new monomers which are polymerized to create coatings found to be resistant to biofilm formation by six different bacterial pathogens: Pseudomonas aeruginosa, Proteus mirabilis, Enterococcus faecalis, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus.
Citation
Dundas, A. A., Sanni, O., Dubern, J., Dimitrakis, G., Hook, A. L., Irvine, D. J., …Alexander, M. R. (2019). Validating a Predictive Structure-Property Relationship by Discovery of Novel Polymers which Reduce Bacterial Biofilm Formation. Advanced Materials, 31(49), Article 1903513. https://doi.org/10.1002/adma.201903513
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 3, 2019 |
Online Publication Date | Oct 3, 2019 |
Publication Date | Dec 6, 2019 |
Deposit Date | Sep 13, 2019 |
Publicly Available Date | Oct 9, 2019 |
Journal | Advanced Materials |
Print ISSN | 0935-9648 |
Electronic ISSN | 1521-4095 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 31 |
Issue | 49 |
Article Number | 1903513 |
DOI | https://doi.org/10.1002/adma.201903513 |
Keywords | low-fouling; polymer microarray; QSAR; transesterification; biofilms |
Public URL | https://nottingham-repository.worktribe.com/output/2612269 |
Publisher URL | https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201903513 |
Additional Information | Received: 2019-06-03; Published: 2019-10-03 |
Files
adma.201903513
(1.1 Mb)
PDF
Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/
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