Cyrus Nouraee
A Brief Review of Edema-Adjusted Infarct Volume Measurement Techniques for Rodent Focal Cerebral Ischemia Models with Practical Recommendations
Nouraee, Cyrus; Fisher, Marc; Napoli, Mario Di; Salazar, Pascal; Farr, Tracy D.; Jafarli, Alibay; Divani, Afshin A.
Authors
Marc Fisher
Mario Di Napoli
Pascal Salazar
TRACY FARR T.Farr@nottingham.ac.uk
Associate Professor
Alibay Jafarli
Afshin A. Divani
Abstract
Background-Determining cerebral infarction volume is an important part of preclinical studies to determine the benefit of potential therapies on stroke outcome. A well-known problem in determining the actual infarction volume of rodent models is the presence of edema. Because of this, algorithms must be utilized to obtain the edema-adjusted (E A)-infarct volume. Different methods based on 2,3,5-triphenyltetrazolium hydrochloride (TTC) staining have been published describing algorithms to determine the E A-infarct volume .
Citation
Nouraee, C., Fisher, M., Napoli, M. D., Salazar, P., Farr, T. D., Jafarli, A., & Divani, A. A. (2019). A Brief Review of Edema-Adjusted Infarct Volume Measurement Techniques for Rodent Focal Cerebral Ischemia Models with Practical Recommendations. Journal of Vascular and Interventional Neurology, 10(3), 38-45
Journal Article Type | Article |
---|---|
Acceptance Date | May 1, 2019 |
Online Publication Date | May 10, 2019 |
Publication Date | 2019-05 |
Deposit Date | Jul 31, 2019 |
Publicly Available Date | Mar 28, 2024 |
Journal | Journal of Vascular and Interventional Neurology |
Print ISSN | 1941-5893 |
Electronic ISSN | 1944-141X |
Publisher | Zeenat Qureshi Stroke Research Center |
Peer Reviewed | Peer Reviewed |
Volume | 10 |
Issue | 3 |
Pages | 38-45 |
Keywords | Stroke model; Rodents; Tetrazolium salt; Focal cerebral ischemia; Cerebral infarction measurement; 2,3,5-triphenyltetrazolium hydrochloride (TTC) |
Public URL | https://nottingham-repository.worktribe.com/output/2361855 |
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