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A Brief Review of Edema-Adjusted Infarct Volume Measurement Techniques for Rodent Focal Cerebral Ischemia Models with Practical Recommendations

Nouraee, Cyrus; Fisher, Marc; Napoli, Mario Di; Salazar, Pascal; Farr, Tracy D.; Jafarli, Alibay; Divani, Afshin A.

Authors

Cyrus Nouraee

Marc Fisher

Mario Di Napoli

Pascal Salazar

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TRACY FARR T.Farr@nottingham.ac.uk
Associate Professor

Alibay Jafarli

Afshin A. Divani



Abstract

Background-Determining cerebral infarction volume is an important part of preclinical studies to determine the benefit of potential therapies on stroke outcome. A well-known problem in determining the actual infarction volume of rodent models is the presence of edema. Because of this, algorithms must be utilized to obtain the edema-adjusted (E A)-infarct volume. Different methods based on 2,3,5-triphenyltetrazolium hydrochloride (TTC) staining have been published describing algorithms to determine the E A-infarct volume .

Citation

Nouraee, C., Fisher, M., Napoli, M. D., Salazar, P., Farr, T. D., Jafarli, A., & Divani, A. A. (2019). A Brief Review of Edema-Adjusted Infarct Volume Measurement Techniques for Rodent Focal Cerebral Ischemia Models with Practical Recommendations. Journal of Vascular and Interventional Neurology, 10(3), 38-45

Journal Article Type Article
Acceptance Date May 1, 2019
Online Publication Date May 10, 2019
Publication Date 2019-05
Deposit Date Jul 31, 2019
Publicly Available Date Mar 28, 2024
Journal Journal of Vascular and Interventional Neurology
Print ISSN 1941-5893
Electronic ISSN 1944-141X
Publisher Zeenat Qureshi Stroke Research Center
Peer Reviewed Peer Reviewed
Volume 10
Issue 3
Pages 38-45
Keywords Stroke model; Rodents; Tetrazolium salt; Focal cerebral ischemia; Cerebral infarction measurement; 2,3,5-triphenyltetrazolium hydrochloride (TTC)
Public URL https://nottingham-repository.worktribe.com/output/2361855