Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection

Venkatesan, Sudhir; Myles, Puja R; Bolton, Kirsty J; Muthuri, Stella G.; Al Khuwaitir, Tarig; Anovadiya, Ashish P; Azziz-Baumgartner, Eduardo; Khandaker, Gulam; Bajjou, Tahar; Bassetti, Matteo; Beovic, Bojana; Bertisch, Barbara; Bonmarin, Isabelle; Booy, Robert; Borja-Aburto, Victor H; Burgmann, Heinz; Cao, Bin; Carratala, Jordi; Chinbayar, Tserendorj; Cilloniz, Catia; Denholm, Justin T; Dominguez, Samuel R; Duarte, Pericles A D; Dubnov-Raz, Gal; Fanella, Sergio; Gao, Zhancheng; G?rardin, Patrick; Giannella, Maddalena; Gubbels, Sophie; Herberg, Jethro; Higuera Iglesias, Anjarath Lorena; Hoeger, Peter H; Hu, Xiao Yun; Islam, Quazi T; Jim?nez, Mirela F.; Keijzers, Gerben; Khalili, Hossein; Kusznierz, Gabriela; Kuzman, Ilija; Langenegger, Eduard; Lankarani, Kamran B; Leo, Yee-Sin; Libster, Romina P.; Linko, Rita; Madanat, Faris; Maltezos, Efstratios; Mamun, Abdullah; Manabe, Toshie; Metan, Gokhan; Miki?, Dragan; Mohn, Kristin G I; Mickiene, Auks?; Oliva, Maria E; Ozkan, Mehpare; Parekh,...

Abstract

© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: [e-mail]. BACKGROUND: The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. METHODS: We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS of

Citation

Venkatesan, S., Myles, P. R., Bolton, K. J., Muthuri, S. G., Al Khuwaitir, T., Anovadiya, A. P., …Nguyen-Van-Tam, J. S. (2020). Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection. Journal of Infectious Diseases, 221(3), 356–366. https://doi.org/10.1093/infdis/jiz152

• Journal Article Type: Article
• Acceptance Date: Mar 5, 2019
• Online Publication Date: Jul 17, 2019
• Publication Date: 2020-02
• Deposit Date: May 8, 2019
• Publicly Available Date: Jul 18, 2020
• Journal: The Journal of Infectious Diseases
• Print ISSN: 1537-6613
• Electronic ISSN: 1537-6613
• Publisher: Oxford University Press (OUP)
• Peer Reviewed: Peer Reviewed
• Volume: 221
• Issue: 3
• Pages: 356–366
• DOI: https://doi.org/10.1093/infdis/jiz152
• Keywords: Immunology and Allergy; Infectious Diseases
• Public URL: https://nottingham-repository.worktribe.com/output/2031431
• Publisher URL: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiz152/5533434