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Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling

Starr, Nichola J.; Hamid, Khuriah Abdul; Wibawa, Judata; Marlow, Ian; Bell, Mike; Pérez-García, Luïsa; Barrett, David A.; Scurr, David J.

Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling Thumbnail


Authors

Khuriah Abdul Hamid

Judata Wibawa

Ian Marlow

Mike Bell

Luïsa Pérez-García

David A. Barrett

DAVID SCURR DAVID.SCURR@NOTTINGHAM.AC.UK
Principal Research Fellow



Abstract

Vitamin C (ascorbic acid) is a naturally occurring, powerful anti-oxidant with the potential to deliver numerous benefits to the skin when applied topically. However, topical use of this compound is currently restricted by an instability in traditional formulations and the delivery and eventual fate of precursor compounds has been largely unexplored. Time of flight secondary ion mass spectrometry (ToF-SIMS) is an emerging technique in the field of skin research and offers detailed chemical analysis, with high mass and spatial resolution, as well as profiling capabilities that allow analysis as a function of sample depth. This work demonstrates the successful use of ToF-SIMS to obtain, in situ, accurate 3D permeation profiles of both ascorbic acid and a popular precursor, ascorbyl glucoside, from ex vivo porcine skin. The significant permeation enhancing effect of a supramolecular hydrogel formulation, produced from an amphiphilic gemini imidazolium-based surfactant, was also demonstrated for both compounds. Using ToF-SIMS, it was also possible to detect and track the breakdown of ascorbyl glucoside into ascorbic acid, elucidating the ability of the hydrogel formulation to preserve this important conversion until the targeted epidermal layer has been reached. This work demonstrates the potential of ToF-SIMS to provide 3D permeation profiles collected in situ from ex vivo tissue samples, offering detailed analysis on compound localisation and degradation. This type of analysis has significant advantages in the area of skin permeation, but can also be readily translated to other tissue types.

Citation

Starr, N. J., Hamid, K. A., Wibawa, J., Marlow, I., Bell, M., Pérez-García, L., …Scurr, D. J. (2019). Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling. International Journal of Pharmaceutics, 563, 21-29. https://doi.org/10.1016/j.ijpharm.2019.03.028

Journal Article Type Article
Acceptance Date Mar 14, 2019
Online Publication Date Mar 15, 2019
Publication Date May 30, 2019
Deposit Date Apr 30, 2019
Publicly Available Date Mar 16, 2020
Journal International Journal of Pharmaceutics
Print ISSN 0378-5173
Electronic ISSN 1873-3476
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 563
Pages 21-29
DOI https://doi.org/10.1016/j.ijpharm.2019.03.028
Keywords Skin permeation; Supramolecular hydrogel; Permeation enhancer; Vitamin C; ToF-SIMS; Depth profiling
Public URL https://nottingham-repository.worktribe.com/output/1867895
Publisher URL https://www.sciencedirect.com/science/article/pii/S0378517319302145?via%3Dihub
Additional Information This article is maintained by: Elsevier; Article Title: Enhanced vitamin C skin permeation from supramolecular hydrogels, illustrated using in situ ToF-SIMS 3D chemical profiling; Journal Title: International Journal of Pharmaceutics; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.ijpharm.2019.03.028; Content Type: article; Copyright: © 2019 Published by Elsevier B.V.

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