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Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II)

Chinchilla, Sandra P.; Doherty, Michael; Abhishek, Abhishek


Sandra P. Chinchilla

Michael Doherty


Objectives: To examine the predictive validity of the Gout Activity Score (GAS), its’ correlation with the Gout Impact Scale (GIS), and their sensitivity to change.

Methods: Data from a clinical trial in which participants with ≥1 gout flare in the previous year were recruited from primary-care, and randomized to nurse-led or continuing usual care were used in this study. GAS and GIS were calculated as described, with higher scores indicating worse disease activity and quality of life respectively. Correlation between GAS and GIS was examined using Spearman’s correlation. Standardized response means (SRMs) were calculated to assess sensitivity to change. The association between GAS at baseline and number of flares in the next 12 months was evaluated using Poisson regression. Data analyses were performed using STATA version 14, with p [less than] 0.05 being statistically significant.

Results: There was low positive correlation between GAS and gout concern overall, and unmet treatment need subscales of GIS (r = 0.34-0.45). Female sex associated independently with fewer gout flares, while increasing GAS, body mass index, and age associated independently with frequent flares. Of all the outcome measures examined, GAS was the most responsive to change (SRMs 0.89 to -0.53). Of the GIS domains, the gout concern overall domain had the best sensitivity to change (SRMs 1.06 to 0.01).

Conclusion: GAS is sensitive to change, has predictive validity, and, correlates with relevant domains of GIS such as gout concern overall. Additional independent validation of GAS is required before it can be adopted in clinical practice.


Chinchilla, S. P., Doherty, M., & Abhishek, A. (2019). Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II). Rheumatology, 58(8), 1378-1382.

Journal Article Type Article
Acceptance Date Dec 13, 2018
Online Publication Date Feb 4, 2019
Publication Date Aug 1, 2019
Deposit Date Jan 8, 2019
Publicly Available Date Feb 7, 2019
Journal Rheumatology
Electronic ISSN 1462-0332
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 58
Issue 8
Pages 1378-1382
Keywords Gout; Disease activity; Quality of life
Public URL
Publisher URL


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