Skip to main content

Research Repository

Advanced Search

Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic

Fuller, Amy; Hancox, Jennie; Vedhara, Kavita; Card, Tim; Mallen, Christian; Van-Tam, Jonathan S. Nguyen; Abhishek, Abhishek

Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic Thumbnail


Authors

AMY FULLER Amy.Fuller@nottingham.ac.uk
Research Fellow

Jennie Hancox

Kavita Vedhara

Dr TIM CARD tim.card@nottingham.ac.uk
Clinical Associate Professor

Christian Mallen

Jonathan S. Nguyen Van-Tam



Contributors

Latika Gupta
Editor

Abstract

Objectives To explore barriers and facilitators to COVID-19, influenza, and pneumococcal vaccine uptake in immunosuppressed adults with immune-mediated inflammatory diseases (IMIDs). Methods Recruiting through national patient charities and a local hospital, participants were invited to take part in an in-depth, one-to-one, semi-structured interview with a trained qualitative researcher between November 2021 and January 2022. Data were analysed thematically in NVivo, cross-validated by a second coder and mapped to the SAGE vaccine hesitancy matrix. Results Twenty participants (75% female, 20% non-white) were recruited. Barriers and facilitators spanned contextual, individual/group and vaccine/vaccination-specific factors. Key facilitators to all vaccines were higher perceived infection risk and belief that vaccination is beneficial. Key barriers to all vaccines were belief that vaccination could trigger IMID flare, and active IMID. Key facilitators specific to COVID-19 vaccines included media focus, high incidence, mass-vaccination programme with visible impact, social responsibility, and healthcare professionals' (HCP) confirmation of the new vaccines' suitability for their IMID. Novel vaccine technology was a concern, not a barrier. Key facilitators of influenza/pneumococcal vaccines were awareness of eligibility, direct invitation, and, clear recommendation from trusted HCP. Key barriers of influenza/pneumococcal vaccines were unaware of eligibility, no direct invitation or recommendation from HCP, low perceived infection risk, and no perceived benefit from vaccination. Conclusions Numerous barriers and facilitators to vaccination, varying by vaccine-type, exist for immunosuppressed- IMID patients. Addressing vaccine benefits and safety for IMID-patients in clinical practice, direct invitation, and public-health messaging highlighting immunosuppression as key vaccination-eligibility criteria may optimise uptake, although further research should assess this.

Citation

Fuller, A., Hancox, J., Vedhara, K., Card, T., Mallen, C., Van-Tam, J. S. N., & Abhishek, A. (2022). Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic. PLoS ONE, 17(9), Article e0267769. https://doi.org/10.1371/journal.pone.0267769

Journal Article Type Article
Acceptance Date Aug 12, 2022
Online Publication Date Sep 9, 2022
Publication Date Sep 1, 2022
Deposit Date Aug 18, 2022
Publicly Available Date Aug 18, 2022
Journal PLOS ONE
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 17
Issue 9
Article Number e0267769
DOI https://doi.org/10.1371/journal.pone.0267769
Keywords Multidisciplinary
Public URL https://nottingham-repository.worktribe.com/output/10080700
Publisher URL https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0267769

Files

Barriers and facilitators to vaccination uptake against COVID-19, influenza, and pneumococcal pneumonia in immunosuppressed adults with immune-mediated inflammatory diseases: A qualitative interview study during the COVID-19 pandemic (608 Kb)
PDF

Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/





You might also like



Downloadable Citations