Barbara Ruggeri
Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis
Ruggeri, Barbara; Nymberg, Charlotte; Vuoksimaa, Eero; Lourdusamy, Anbarasu; Wong, Cybele P.; Carvalho, Fabiana M.; Jia, Tianye; Cattrell, Anna; Macare, Christine; Banaschewski, Tobias; Barker, Gareth J.; Bokde, Arun L.W.; Bromberg, Uli; B�chel, Christian; Conrod, Patricia J.; Fauth-B�hler, Mira; Flor, Herta; Frouin, Vincent; Gallinat, J�rgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Nees, Frauke; Pausova, Zdenka; Paus, Tom�; Rietschel, Marcella; Robbins, Trevor; Smolka, Michael N.; Spanagel, Rainer; Bakalkin, Georgy; Mill, Jonathan; Sommer, Wolfgang H.; Rose, Richard J.; Yan, Jia; Aliev, Fazil; Dick, Danielle; Kaprio, Jaakko; Desrivi�res, Sylvane; Schumann, Gunter
Authors
Charlotte Nymberg
Eero Vuoksimaa
AROCKIA LOURDUSAMY ANBARASU.LOURDUSAMY@NOTTINGHAM.AC.UK
Senior Research Fellow
Cybele P. Wong
Fabiana M. Carvalho
Tianye Jia
Anna Cattrell
Christine Macare
Tobias Banaschewski
Gareth J. Barker
Arun L.W. Bokde
Uli Bromberg
Christian B�chel
Patricia J. Conrod
Mira Fauth-B�hler
Herta Flor
Vincent Frouin
J�rgen Gallinat
Hugh Garavan
Professor PENNY GOWLAND PENNY.GOWLAND@NOTTINGHAM.AC.UK
Professor of Physics
Andreas Heinz
Bernd Ittermann
Jean-Luc Martinot
Frauke Nees
Zdenka Pausova
Tom� Paus
Marcella Rietschel
Trevor Robbins
Michael N. Smolka
Rainer Spanagel
Georgy Bakalkin
Jonathan Mill
Wolfgang H. Sommer
Richard J. Rose
Jia Yan
Fazil Aliev
Danielle Dick
Jaakko Kaprio
Sylvane Desrivi�res
Gunter Schumann
Abstract
Objective: The genetic component of alcohol use disorder is substantial, but monozygotic twin discordance indicates a role for nonheritable differences that could be mediated by epigenetics. Despite growing evidence associating epigenetics and psychiatric disorders, it is unclear how epigenetics, particularly DNA methylation, relate to brain function and behavior, including drinking behavior.
Method: The authors carried out a genome-wide analysis of DNA methylation of 18 monozygotic twin pairs discordant for alcohol use disorder and validated differentially methylated regions. After validation, the authors characterized these differentially methylated regions using personality trait assessment and functional MRI in a sample of 499 adolescents.
Results: Hypermethylation in the 3?-protein-phosphatase-1G (PPM1G) gene locus was associated with alcohol use disorder. The authors found association of PPM1G hypermethylation with early escalation of alcohol use and increased impulsiveness. They also observed association of PPM1G hypermethylation with increased blood-oxygen-level-dependent response in the right subthalamic nucleus during an impulsiveness task.
Conclusions: Overall, the authors provide first evidence for an epigenetic marker associated with alcohol consumption and its underlying neurobehavioral phenotype.
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 23, 2014 |
Online Publication Date | May 18, 2015 |
Publication Date | Jun 1, 2015 |
Deposit Date | May 17, 2018 |
Journal | American Journal of Psychiatry |
Electronic ISSN | 1535-7228 |
Publisher | American Psychiatric Publishing |
Peer Reviewed | Peer Reviewed |
Volume | 172 |
Issue | 6 |
Pages | 543-552 |
DOI | https://doi.org/10.1176/appi.ajp.2014.14030382 |
Public URL | http://www.ncbi.nlm.nih.gov/pubmed/25982659 |
Publisher URL | https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2014.14030382 |
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