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Effect of delivery method on the efficacy of Salmonella vaccination in chickens

Atterbury, Robert J.; Morris, V.; Harrison, D.; Tucker, V.; Allen, V.M.; Davies, R.H.; Carrique-Mas, J.J.

Authors

V. Morris

D. Harrison

V. Tucker

V.M. Allen

R.H. Davies

J.J. Carrique-Mas



Abstract

To investigate whether the efficacy of live vaccines is influenced by the mode of vaccine delivery, a widely-used UK live commercial Salmonella Enteritidis vaccine was delivered to pullet chicks either by spray, in drinking water, or in combination with a bivalent vaccine containing inactivated Salmonella Enteritidis and Salmonella Typhimurium. The birds were subsequently challenged with 102 or 108 colony-forming units (cfu) of Salmonella Enteritidis through drinking water at either six or 20 weeks of age. Ten days after the challenge, the birds were euthanased and their caecal contents cultured for Salmonella. All of the vaccinated groups contained fewer Salmonella Enteritidis-positive birds than the unvaccinated groups. The ‘spray-vaccinated’ group contained significantly fewer Salmonella Enteritidis-positive birds than the ‘water-vaccinated’ group after challenge with 108 cfu at 20 weeks. However, there was little or no difference at the other challenge time points between the groups that received vaccine through different modes of delivery.

Citation

Atterbury, R. J., Morris, V., Harrison, D., Tucker, V., Allen, V., Davies, R., & Carrique-Mas, J. (2010). Effect of delivery method on the efficacy of Salmonella vaccination in chickens. Veterinary Record, 167(5), doi:10.1136/vr.b4884

Journal Article Type Article
Acceptance Date Jul 31, 2010
Online Publication Date Jul 31, 2010
Publication Date Jul 1, 2010
Deposit Date Aug 30, 2017
Publicly Available Date
Journal Veterinary Record
Print ISSN 0042-4900
Electronic ISSN 2042-7670
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 167
Issue 5
DOI https://doi.org/10.1136/vr.b4884
Public URL http://eprints.nottingham.ac.uk/id/eprint/45240
Publisher URL http://veterinaryrecord.bmj.com/content/167/5/161#
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf