Outputs (27)

A novel small molecule ZYZ384 targeting SMYD3 for hepatocellular carcinoma via reducing H3K4 trimethylation of the Rac1 promoter (2024)
Journal Article
Ding, Q., Cai, J., Jin, L., Hu, W., Song, W., Rose, P., Tang, Z., Zhan, Y., Bao, L., Lei, W., & Zhu, Y. Z. (2024). A novel small molecule ZYZ384 targeting SMYD3 for hepatocellular carcinoma via reducing H3K4 trimethylation of the Rac1 promoter. MedComm, 5(10), Article e711. https://doi.org/10.1002/mco2.711

SMYD3 (SET and MYND domain-containing 3) is a histone lysine methyltransferase highly expressed in different types of cancer(s) and is a promising epigenetic target for developing novel antitumor therapeutics. No selective inhibitors for this protein... Read More about A novel small molecule ZYZ384 targeting SMYD3 for hepatocellular carcinoma via reducing H3K4 trimethylation of the Rac1 promoter.

Magnolol Loaded Polydopamine-Chitosan Coated pH-responsive Nanoparticles for Alleviation of Ulcerative Colitis (2024)
Journal Article
Mu, G., Peng, F., Zhang, Z., M. Brameld, J., Rose, P., Yang, X., Jiang, Z.-J., He, X., & Tang, B. (2024). Magnolol Loaded Polydopamine-Chitosan Coated pH-responsive Nanoparticles for Alleviation of Ulcerative Colitis. Journal of Drug Delivery Science and Technology, 101(Part A), Article 106151. https://doi.org/10.1016/j.jddst.2024.106151

This study designed and developed a novel three-layer electrostatic, slow-releasing nanoparticle drug delivery system for the treatment of ulcerative colitis. The nanoparticles were composed of layers of zein-based polydopamine, chitosan and cellulos... Read More about Magnolol Loaded Polydopamine-Chitosan Coated pH-responsive Nanoparticles for Alleviation of Ulcerative Colitis.

Mineral supplements in Aging (2023)
Book Chapter
Welham, S., Rose, P., Coneyworth, L., Avery, A., & Kirk, C. Mineral supplements in Aging. In Biochemistry and Cell Biology of Ageing: Part V, Anti-ageing Interventions. Springer

With advancing age, achievement of dietary adequacy for all nutrients is increasingly difficult and this is particularly so for minerals. Various factors impede mineral acquisition and absorption including reduced appetite, depressed gastric acid pro... Read More about Mineral supplements in Aging.

Update on the global prevalence and severity of kiwifruit allergy: a scoping review (2023)
Journal Article
James, C. A., Welham, S., & Rose, P. (2023). Update on the global prevalence and severity of kiwifruit allergy: a scoping review. International Journal of Food Science and Technology, 58(12), 6158-6181. https://doi.org/10.1111/ijfs.16680

The production and use of kiwifruit, and their derived products, has seen rapid growth in the food industry with some 4,467,099 tonnes produced in 2021. A key area of development has been the increased use of kiwifruit waste streams to support sustai... Read More about Update on the global prevalence and severity of kiwifruit allergy: a scoping review.

The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals (2023)
Journal Article
Alsaeedi, A., Welham, S., Rose, P., & Zhu, Y.-Z. (2023). The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals. Antioxidants, 12(4), Article 908. https://doi.org/10.3390/antiox12040908

Mammalian cells and tissues have the capacity to generate hydrogen sulfide gas (H2S) via catabolic routes involving cysteine metabolism. H2S acts on cell signaling cascades that are necessary in many biochemical and physiological roles important in t... Read More about The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals.

Signaling pathways in rheumatoid arthritis: implications for targeted therapy (2023)
Journal Article
Ding, Q., Hu, W., Wang, R., Yang, Q., Zhu, M., Li, M., …Zhu, Y. Z. (2023). Signaling pathways in rheumatoid arthritis: implications for targeted therapy. Signal Transduction and Targeted Therapy, 8, Article 68. https://doi.org/10.1038/s41392-023-01331-9

Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression leads to joint deformity and associated loss of function, which significantly impacts the quality of life for sufferers and adds to losses in the labor force.... Read More about Signaling pathways in rheumatoid arthritis: implications for targeted therapy.

Impact of lifestyle factors on dietary vitamin B6 intake and plasma pyridoxal 5'-phosphate level in UK adults: National Diet and Nutrition Survey Rolling Programme (NDNS) (2008-2017) (2023)
Journal Article
Alsaeedi, A., Welham, S., & Rose, P. (2023). Impact of lifestyle factors on dietary vitamin B6 intake and plasma pyridoxal 5'-phosphate level in UK adults: National Diet and Nutrition Survey Rolling Programme (NDNS) (2008-2017). British Journal of Nutrition, 130(8), 1403-1415. https://doi.org/10.1017/S0007114523000417

Reduction in dietary vitamin B6 intakes is associated with increased relative risk of diseases such as cancer, atherosclerosis, and cognitive dysfunction. All forms of dietary vitamin B6 are converted to pyridoxal 5'-phosphate (PLP), that is needed f... Read More about Impact of lifestyle factors on dietary vitamin B6 intake and plasma pyridoxal 5'-phosphate level in UK adults: National Diet and Nutrition Survey Rolling Programme (NDNS) (2008-2017).

Recent updates in click and computational chemistry for drug discovery and development (2023)
Journal Article
Cai, J. H., Zhu, X. Z., Guo, P. Y., Rose, P., Liu, X. T., Liu, X., & Zhu, Y. Z. (2023). Recent updates in click and computational chemistry for drug discovery and development. Frontiers in Chemistry, 11, Article 1114970. https://doi.org/10.3389/fchem.2023.1114970

Drug discovery is a costly and time-consuming process with a very high failure rate. Recently, click chemistry and computer-aided drug design (CADD) represent popular areas for new drug development. Herein, we summarized the recent updates in click a... Read More about Recent updates in click and computational chemistry for drug discovery and development.

The Impact of the COVID-19 Pandemic on the Food Security of UK Adults Aged 20–65 Years (COVID-19 Food Security and Dietary Assessment Study) (2022)
Journal Article
Thomas, M., Eveleigh, E., Vural, Z., Rose, P., Avery, A., Coneyworth, L., & Welham, S. (2022). The Impact of the COVID-19 Pandemic on the Food Security of UK Adults Aged 20–65 Years (COVID-19 Food Security and Dietary Assessment Study). Nutrients, 14(23), Article 5078. https://doi.org/10.3390/nu14235078

The first UK lockdown greatly impacted the food security status of UK adults. This study set out to establish if food procurement was adapted differently for different income groups and if this impacted dietary intakes disproportionately. Adults (n=5... Read More about The Impact of the COVID-19 Pandemic on the Food Security of UK Adults Aged 20–65 Years (COVID-19 Food Security and Dietary Assessment Study).

Edible algae allergenicity – a short report (2022)
Journal Article
James, C. A., Welham, S., & Rose, P. (2023). Edible algae allergenicity – a short report. Journal of Applied Phycology, 35(1), 339–352. https://doi.org/10.1007/s10811-022-02880-2

The use of seaweed and algal derived products in the food industry has grown rapidly in recent times. Major areas of expansion have been in Western countries where algal derived commodities are being utilised as edible foods or sources of high value... Read More about Edible algae allergenicity – a short report.