Outputs (41)

Sloppiness in Spontaneously Active Neuronal Networks (2015)
Journal Article
Panas, D., Amin, H., Maccione, A., Muthmann, O., van Rossum, M., Berdondini, L., & Hennig, M. H. (2015). Sloppiness in Spontaneously Active Neuronal Networks. Journal of Neuroscience, 35(22), 8480-8492. https://doi.org/10.1523/jneurosci.4421-14.2015

Various plasticity mechanisms, including experience-dependent, spontaneous, as well as homeostatic ones, continuously remodel neural circuits. Yet, despite fluctuations in the properties of single neurons and synapses, the behavior and function of ne... Read More about Sloppiness in Spontaneously Active Neuronal Networks.

Cellular mechanisms underlying behavioral state-dependent bidirectional modulation of motor cortex output (2015)
Journal Article
Schiemann, J., Puggioni, P., Dacre, J., Pelko, M., Domanski, A., van Rossum, M. C., & Duguid, I. (2015). Cellular mechanisms underlying behavioral state-dependent bidirectional modulation of motor cortex output. Cell Reports, 11(8), https://doi.org/10.1016/j.celrep.2015.04.042

Neuronal activity in primary motor cortex (M1) correlates with behavioral state, but the cellular mechanisms underpinning behavioral state-dependent modulation of M1 output remain largely unresolved. Here, we performed in vivo patch-clamp recordings... Read More about Cellular mechanisms underlying behavioral state-dependent bidirectional modulation of motor cortex output.

Spontaneous action potentials and neural coding in unmyelinated axons (2015)
Journal Article
O'Donnell, C., & van Rossum, M. C. (2015). Spontaneous action potentials and neural coding in unmyelinated axons. Neural Computation, 27(4), https://doi.org/10.1162/NECO_a_00705

The voltage-gated Na and K channels in neurons are responsible for action potential generation. Because ion channels open and close in a stochastic fashion, spontaneous (ectopic) action potentials can result even in the absence of stimulation. While... Read More about Spontaneous action potentials and neural coding in unmyelinated axons.

Independent theta phase coding accounts for CA1 population sequences and enables flexible remapping (2015)
Journal Article
Chadwick, A., van Rossum, M. C., & Nolan, M. F. (2015). Independent theta phase coding accounts for CA1 population sequences and enables flexible remapping. eLife, 4, Article e03542. https://doi.org/10.7554/eLife.03542

Hippocampal place cells encode an animal's past, current, and future location through sequences of action potentials generated within each cycle of the network theta rhythm. These sequential representations have been suggested to result from temporal... Read More about Independent theta phase coding accounts for CA1 population sequences and enables flexible remapping.

Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise (2014)
Journal Article
O'Donnell, C., & van Rossum, M. C. (2014). Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise. Frontiers in Computational Neuroscience, 8, https://doi.org/10.3389/fncom.2014.00105

Electrical signaling in neurons is mediated by the opening and closing of large numbers of individual ion channels. The ion channels' state transitions are stochastic and introduce fluctuations in the macroscopic current through ion channel populatio... Read More about Systematic analysis of the contributions of stochastic voltage gated channels to neuronal noise.

Probabilistic inference of short-term synaptic plasticity in neocortical microcircuits (2013)
Journal Article
Costa, R. P., Sjöström, P. J., & van Rossum, M. C. (2013). Probabilistic inference of short-term synaptic plasticity in neocortical microcircuits. Frontiers in Computational Neuroscience, 7, https://doi.org/10.3389/fncom.2013.00075

Short-term synaptic plasticity is highly diverse across brain area, cortical layer, cell type, and developmental stage. Since short-term plasticity (STP) strongly shapes neural dynamics, this diversity suggests a specific and essential role in neural... Read More about Probabilistic inference of short-term synaptic plasticity in neocortical microcircuits.

Feedback inhibition enables theta-nested gamma oscillations and grid firing fields (2013)
Journal Article
Pastoll, H., Solanka, L., van Rossum, M. C., & Nolan, M. F. (2013). Feedback inhibition enables theta-nested gamma oscillations and grid firing fields. Neuron, 77(1), https://doi.org/10.1016/j.neuron.2012.11.032

Cortical circuits are thought to multiplex firing rate codes with temporal codes that rely on oscillatory network activity, but the circuit mechanisms that combine these coding schemes are unclear. We establish with optogenetic activation of layer II... Read More about Feedback inhibition enables theta-nested gamma oscillations and grid firing fields.

Soft-bound synaptic plasticity increases storage capacity (2012)
Journal Article
van Rossum, M. C., Shippi, M., & Barrett, A. B. (2012). Soft-bound synaptic plasticity increases storage capacity. PLoS Computational Biology, 8(12), Article e1002836. https://doi.org/10.1371/journal.pcbi.1002836

Accurate models of synaptic plasticity are essential to understand the adaptive properties of the nervous system and for realistic models of learning and memory. Experiments have shown that synaptic plasticity depends not only on pre- and post-synapt... Read More about Soft-bound synaptic plasticity increases storage capacity.

Systematic biases in early ERP and ERF components as a result of high-pass filtering (2012)
Journal Article
Acunzo, D. J., Mackenzie, G., & van Rossum, M. C. (2012). Systematic biases in early ERP and ERF components as a result of high-pass filtering. Journal of Neuroscience Methods, 209(1), https://doi.org/10.1016/j.jneumeth.2012.06.011

The event-related potential (ERP) and event-related field (ERF) techniques provide valuable insights into the time course of processes in the brain. Because neural signals are typically weak, researchers commonly filter the data to increase the signa... Read More about Systematic biases in early ERP and ERF components as a result of high-pass filtering.

Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge (2011)
Journal Article
Feldwisch-Drentrup, H., Barrett, A. B., Smith, M. T., & van Rossum, M. C. (2012). Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge. Journal of Neuroscience Methods, 210(1), https://doi.org/10.1016/j.jneumeth.2011.11.004

Synaptic channels are stochastic devices. Even recording from large ensembles of channels, the fluctuations, described by Markov transition matrices, can be used to extract single channel properties. Here we study fluctuations in the open time of cha... Read More about Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge.