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Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge

Feldwisch-Drentrup, Hinnerk; Barrett, Adam B.; Smith, Michael T.; van Rossum, Mark C.W.

Authors

Hinnerk Feldwisch-Drentrup

Adam B. Barrett

Michael T. Smith

Mark C.W. van Rossum

Abstract

Synaptic channels are stochastic devices. Even recording from large ensembles of channels, the fluctuations, described by Markov transition matrices, can be used to extract single channel properties. Here we study fluctuations in the open time of channels, which is proportional to the charge flowing through the channel. We use the results to implement a novel type of noise analysis that uses the charge rather than the current to extract fundamental channel parameters. We show in simulations that this charge based noise analysis is more robust if the synapse is located on the dendrites and thus subject to cable filtering. However, we also demonstrate that when multiple synapses are distributed on the dendrites, noise analysis breaks down. We finally discuss applications of our results to other biological processes.

Journal Article Type Article
Publication Date Sep 15, 2012
Journal Journal of Neuroscience Methods
Print ISSN 0165-0270
Electronic ISSN 1872-678X
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 210
Issue 1
Institution Citation Feldwisch-Drentrup, H., Barrett, A. B., Smith, M. T., & van Rossum, M. C. (2012). Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge. Journal of Neuroscience Methods, 210(1), doi:10.1016/j.jneumeth.2011.11.004
DOI https://doi.org/10.1016/j.jneumeth.2011.11.004
Keywords Synaptic transmission ; Noise analysis ; Stochastic channels ; Neural variability
Publisher URL https://www.sciencedirect.com/science/article/pii/S0165027011006601?via%3Dihub
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf




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