Skip to main content

Research Repository

Advanced Search

Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge

Feldwisch-Drentrup, Hinnerk; Barrett, Adam B.; Smith, Michael T.; van Rossum, Mark C.W.

Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge Thumbnail


Authors

Hinnerk Feldwisch-Drentrup

Adam B. Barrett

Michael T. Smith

Prof MARK VAN ROSSUM Mark.VanRossum@nottingham.ac.uk
Chair and Director/Neural Computation Research Group



Abstract

Synaptic channels are stochastic devices. Even recording from large ensembles of channels, the fluctuations, described by Markov transition matrices, can be used to extract single channel properties. Here we study fluctuations in the open time of channels, which is proportional to the charge flowing through the channel. We use the results to implement a novel type of noise analysis that uses the charge rather than the current to extract fundamental channel parameters. We show in simulations that this charge based noise analysis is more robust if the synapse is located on the dendrites and thus subject to cable filtering. However, we also demonstrate that when multiple synapses are distributed on the dendrites, noise analysis breaks down. We finally discuss applications of our results to other biological processes.

Citation

Feldwisch-Drentrup, H., Barrett, A. B., Smith, M. T., & van Rossum, M. C. (2012). Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge. Journal of Neuroscience Methods, 210(1), https://doi.org/10.1016/j.jneumeth.2011.11.004

Journal Article Type Article
Acceptance Date Nov 2, 2011
Online Publication Date Nov 15, 2011
Publication Date Sep 15, 2012
Deposit Date Feb 7, 2018
Publicly Available Date Mar 28, 2024
Journal Journal of Neuroscience Methods
Print ISSN 0165-0270
Electronic ISSN 1872-678X
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 210
Issue 1
DOI https://doi.org/10.1016/j.jneumeth.2011.11.004
Keywords Synaptic transmission ; Noise analysis ; Stochastic channels ; Neural variability
Public URL https://nottingham-repository.worktribe.com/output/711403
Publisher URL https://www.sciencedirect.com/science/article/pii/S0165027011006601?via%3Dihub

Files






You might also like



Downloadable Citations