Hinnerk Feldwisch-Drentrup
Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge
Feldwisch-Drentrup, Hinnerk; Barrett, Adam B.; Smith, Michael T.; van Rossum, Mark C.W.
Authors
Adam B. Barrett
Michael T. Smith
Prof MARK VAN ROSSUM Mark.VanRossum@nottingham.ac.uk
Chair and Director/Neural Computation Research Group
Abstract
Synaptic channels are stochastic devices. Even recording from large ensembles of channels, the fluctuations, described by Markov transition matrices, can be used to extract single channel properties. Here we study fluctuations in the open time of channels, which is proportional to the charge flowing through the channel. We use the results to implement a novel type of noise analysis that uses the charge rather than the current to extract fundamental channel parameters. We show in simulations that this charge based noise analysis is more robust if the synapse is located on the dendrites and thus subject to cable filtering. However, we also demonstrate that when multiple synapses are distributed on the dendrites, noise analysis breaks down. We finally discuss applications of our results to other biological processes.
Citation
Feldwisch-Drentrup, H., Barrett, A. B., Smith, M. T., & van Rossum, M. C. (2012). Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge. Journal of Neuroscience Methods, 210(1), https://doi.org/10.1016/j.jneumeth.2011.11.004
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 2, 2011 |
Online Publication Date | Nov 15, 2011 |
Publication Date | Sep 15, 2012 |
Deposit Date | Feb 7, 2018 |
Publicly Available Date | Feb 7, 2018 |
Journal | Journal of Neuroscience Methods |
Print ISSN | 0165-0270 |
Electronic ISSN | 1872-678X |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 210 |
Issue | 1 |
DOI | https://doi.org/10.1016/j.jneumeth.2011.11.004 |
Keywords | Synaptic transmission ; Noise analysis ; Stochastic channels ; Neural variability |
Public URL | https://nottingham-repository.worktribe.com/output/711403 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S0165027011006601?via%3Dihub |
Contract Date | Feb 7, 2018 |
Files
area_r1.pdf
(334 Kb)
PDF
You might also like
Dendritic spine dynamics regulate the long-term stability of synaptic plasticity
(2011)
Journal Article
Systematic biases in early ERP and ERF components as a result of high-pass filtering
(2012)
Journal Article
Soft-bound synaptic plasticity increases storage capacity
(2012)
Journal Article
Feedback inhibition enables theta-nested gamma oscillations and grid firing fields
(2013)
Journal Article
Probabilistic inference of short-term synaptic plasticity in neocortical microcircuits
(2013)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search