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Feedback inhibition enables theta-nested gamma oscillations and grid firing fields

Pastoll, Hugh; Solanka, Lukas; van Rossum, Mark C.W.; Nolan, Matthew F.

Authors

Hugh Pastoll

Lukas Solanka

Mark C.W. van Rossum

Matthew F. Nolan



Abstract

Cortical circuits are thought to multiplex firing rate codes with temporal codes that rely on oscillatory network activity, but the circuit mechanisms that combine these coding schemes are unclear. We establish with optogenetic activation of layer II of the medial entorhinal cortex that theta frequency drive to this circuit is sufficient to generate nested gamma frequency oscillations in synaptic activity. These nested gamma oscillations closely resemble activity during spatial exploration, are generated by local feedback inhibition without recurrent excitation, and have clock-like features suitable as reference signals for multiplexing temporal codes within rate-coded grid firing fields. In network models deduced from our data, feedback inhibition supports coexistence of theta-nested gamma oscillations with attractor states that generate grid firing fields. These results indicate that grid cells communicate primarily via inhibitory interneurons. This circuit mechanism enables multiplexing of oscillation-based temporal codes with rate-coded attractor states.

Citation

Pastoll, H., Solanka, L., van Rossum, M. C., & Nolan, M. F. (2013). Feedback inhibition enables theta-nested gamma oscillations and grid firing fields. Neuron, 77(1), https://doi.org/10.1016/j.neuron.2012.11.032

Journal Article Type Article
Acceptance Date Nov 30, 2012
Publication Date Jan 9, 2013
Deposit Date Jul 11, 2018
Publicly Available Date Jul 11, 2018
Journal Neuron
Print ISSN 0896-6273
Electronic ISSN 1097-4199
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 77
Issue 1
DOI https://doi.org/10.1016/j.neuron.2012.11.032
Public URL http://eprints.nottingham.ac.uk/id/eprint/49638
Publisher URL https://www.sciencedirect.com/science/article/pii/S0896627312011191
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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